Literature DB >> 18468592

Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes.

H Alout1, M Weill.   

Abstract

In natural populations of mosquitoes, high level of resistance to carbamates (CX) and organophosphates (OP) is provided by insensitive acetylcholinesterase (AChE1). Different alleles conferring resistance have been identified at the ace1 locus. They differ from the wild-type by only one amino-acid substitution. The comparison of the biochemical characteristics of mutated recombinant proteins and AChE1 in resistant mosquito extracts confirmed the role of each substitution in insensitivity. Selection of these different resistant alleles in field populations depends likely on the insecticides used locally. Theoretical modelling studies are initiated to develop novel strategies of mosquito control.

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Year:  2008        PMID： 18468592     DOI： 10.1016/j.cbi.2008.03.018

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  15 in total

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Review 2.  Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors.

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3.  Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.

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Journal:  Structure       Date:  2017-12-21       Impact factor: 5.006

4.  Novel AChE inhibitors for sustainable insecticide resistance management.

Authors:  Haoues Alout; Pierrick Labbé; Arnaud Berthomieu; Luc Djogbénou; Jean-Paul Leonetti; Philippe Fort; Mylène Weill
Journal:  PLoS One       Date:  2012-10-08       Impact factor: 3.240

5.  Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae.

Authors:  David Weetman; Sara N Mitchell; Craig S Wilding; Daniel P Birks; Alexander E Yawson; John Essandoh; Henry D Mawejje; Luc S Djogbenou; Keith Steen; Emily J Rippon; Christopher S Clarkson; Stuart G Field; Daniel J Rigden; Martin J Donnelly
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6.  Point mutations associated with organophosphate and carbamate resistance in Chinese strains of Culex pipiens quinquefasciatus (Diptera: Culicidae).

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8.  The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications.

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Journal:  PLoS Biol       Date:  2016-12-05       Impact factor: 8.029

9.  Compensatory mechanisms in resistant Anopheles gambiae AcerKis and KdrKis neurons modulate insecticide-based mosquito control.

Authors:  Stéphane Perrier; Eléonore Moreau; Caroline Deshayes; Marine El-Adouzi; Delphine Goven; Fabrice Chandre; Bruno Lapied
Journal:  Commun Biol       Date:  2021-06-02

10.  Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).

Authors:  Dawn M Wong; Jianyong Li; Qiao-Hong Chen; Qian Han; James M Mutunga; Ania Wysinski; Troy D Anderson; Haizhen Ding; Tiffany L Carpenetti; Astha Verma; Rafique Islam; Sally L Paulson; Polo C-H Lam; Maxim Totrov; Jeffrey R Bloomquist; Paul R Carlier
Journal:  PLoS One       Date:  2012-10-01       Impact factor: 3.240
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