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Literature DB >> 1846850

The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase.

M Ikeda¹, M Wachi, H K Jung, F Ishino, M Matsuhashi.

Abstract

Amplification of the mraY gene, previously called open reading frame Y (ORF-Y, 1,080 bp), at 2 min in the chromosome map of Escherichia coli enhanced the activity of UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase (EC 2.7.8.13). This enzyme catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-N-acetylmuramoyl-pentapeptide and undecaprenyl-phosphate, the first step in the lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans. The enhanced enzyme activity was sensitive to tunicamycin, and the amino tunicamycin-sensitive N-acetylglucosamine-1-phosphate transferase of Saccharomyces cerevisiae. Very probably mraY is the structural gene for the above enzyme.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1846850 PMCID： PMC207220 DOI： 10.1128/jb.173.3.1021-1026.1991

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

18 in total

1. LIPID-PHOSPHOACETYLMURAMYL-PENTAPEPTIDE AND LIPID-PHOSPHODISACCHARIDE-PENTAPEPTIDE: PRESUMED MEMBRANE TRANSPORT INTERMEDIATES IN CELL WALL SYNTHESIS.

Authors: J S ANDERSON; M MATSUHASHI; M A HASKIN; J L STROMINGER
Journal: Proc Natl Acad Sci U S A Date: 1965-04 Impact factor: 11.205

Review 2. Machinery for cell growth and division: penicillin-binding proteins and other proteins.

Authors: M Matsuhashi; M Wachi; F Ishino
Journal: Res Microbiol Date: 1990-01 Impact factor: 3.992

3. Nucleotide sequence of the cell-envelope murG gene of Escherichia coli.

Authors: D Mengin-Lecreulx; L Texier; J van Heijenoort
Journal: Nucleic Acids Res Date: 1990-05-11 Impact factor: 16.971

4. Nucleotide sequence involving murD and an open reading frame ORF-Y spacing murF and ftsW in Escherichia coli.

Authors: M Ikeda; M Wachi; F Ishino; M Matsuhashi
Journal: Nucleic Acids Res Date: 1990-02-25 Impact factor: 16.971

5. Nucleotide sequence involving murG and murC in the mra gene cluster region of Escherichia coli.

Authors: M Ikeda; M Wachi; H K Jung; F Ishino; M Matsuhashi
Journal: Nucleic Acids Res Date: 1990-07-11 Impact factor: 16.971

6. Nucleotide sequence of the murE gene of Escherichia coli.

Authors: J S Tao; E E Ishiguro
Journal: Can J Microbiol Date: 1989-11 Impact factor: 2.419

7. DNA-directed peptide synthesis. II. The synthesis of the alpha-fragment of the enzyme beta-galactosidase.

Authors: J K DeVries; G Zubay
Journal: Proc Natl Acad Sci U S A Date: 1967-04 Impact factor: 11.205

8. Production of single-stranded plasmid DNA.

Authors: J Vieira; J Messing
Journal: Methods Enzymol Date: 1987 Impact factor: 1.600

9. On the process of cellular division in Escherichia coli: nucleotide sequence of the gene for penicillin-binding protein 3.

Authors: M Nakamura; I N Maruyama; M Soma; J Kato; H Suzuki; Y Horota
Journal: Mol Gen Genet Date: 1983

10. A simple method for displaying the hydropathic character of a protein.

Authors: J Kyte; R F Doolittle
Journal: J Mol Biol Date: 1982-05-05 Impact factor: 5.469

39 in total

1. Genetic evidence that the bacteriophage phi X174 lysis protein inhibits cell wall synthesis.

Authors: T G Bernhardt; W D Roof; R Young
Journal: Proc Natl Acad Sci U S A Date: 2000-04-11 Impact factor: 11.205

2. Katanosin B and plusbacin A(3), inhibitors of peptidoglycan synthesis in methicillin-resistant Staphylococcus aureus.

Authors: H Maki; K Miura; Y Yamano
Journal: Antimicrob Agents Chemother Date: 2001-06 Impact factor: 5.191

3. Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes.

Authors: Yi Ma; Daniela Münch; Tanja Schneider; Hans-Georg Sahl; Ahmed Bouhss; Umesh Ghoshdastider; Jufang Wang; Volker Dötsch; Xiaoning Wang; Frank Bernhard
Journal: J Biol Chem Date: 2011-09-20 Impact factor: 5.157

4. Dynamic polar sequestration of excess MurG may regulate enzymatic function.

Authors: Allison M Michaelis; Zemer Gitai
Journal: J Bacteriol Date: 2010-07-19 Impact factor: 3.490

5. The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.

Authors: D Mengin-Lecreulx; L Texier; M Rousseau; J van Heijenoort
Journal: J Bacteriol Date: 1991-08 Impact factor: 3.490

6. Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.

Authors: Masanori Funabashi; Satoshi Baba; Toshio Takatsu; Masaaki Kizuka; Yasuo Ohata; Masahiro Tanaka; Koichi Nonaka; Anatol P Spork; Christian Ducho; Wei-Chen Leyla Chen; Steven G Van Lanen
Journal: Angew Chem Int Ed Engl Date: 2013-09-06 Impact factor: 15.336

10. Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan.

Authors: P Doublet; J van Heijenoort; D Mengin-Lecreulx
Journal: J Bacteriol Date: 1992-09 Impact factor: 3.490