OBJECTIVE: To study the role of Mer receptor tyrosine kinase (mertk) in atherosclerosis. METHODS AND RESULTS: We irradiated and reconstituted atherosclerosis-susceptible C57Bl/6 low-density lipoprotein receptor-deficient female mice (ldlr(-/-)) with either a mertk(+/+) or mertk(-/-) (tyrosine kinase-defective mertk) bone marrow. The mice were put on high-fat diet for either 8 or 15 weeks. Mertk deficiency led to increased accumulation of apoptotic cells within the lesions, promoted a proinflammatory immune response, and accelerated lesion development. CONCLUSIONS: Mertk expression by bone marrow-derived cells is required for the disposal of apoptotic cells and controls lesion development and inflammation.
OBJECTIVE: To study the role of Mer receptor tyrosine kinase (mertk) in atherosclerosis. METHODS AND RESULTS: We irradiated and reconstituted atherosclerosis-susceptible C57Bl/6 low-density lipoprotein receptor-deficient female mice (ldlr(-/-)) with either a mertk(+/+) or mertk(-/-) (tyrosine kinase-defective mertk) bone marrow. The mice were put on high-fat diet for either 8 or 15 weeks. Mertk deficiency led to increased accumulation of apoptotic cells within the lesions, promoted a proinflammatory immune response, and accelerated lesion development. CONCLUSIONS:Mertk expression by bone marrow-derived cells is required for the disposal of apoptotic cells and controls lesion development and inflammation.
Authors: Bishuang Cai; Edward B Thorp; Amanda C Doran; Manikandan Subramanian; Brian E Sansbury; Chyuan-Sheng Lin; Matthew Spite; Gabrielle Fredman; Ira Tabas Journal: Proc Natl Acad Sci U S A Date: 2016-05-19 Impact factor: 11.205
Authors: V A Tyurin; K Balasubramanian; D Winnica; Y Y Tyurina; A S Vikulina; R R He; A A Kapralov; C H Macphee; V E Kagan Journal: Cell Death Differ Date: 2014-01-24 Impact factor: 15.828