BACKGROUND: Up to 1% of the population suffer from coeliac disease. Data on the prevalence in elderly people is scant. We hypothesized that they would over time have developed obvious symptoms. Clinically silent or undiagnosed disease would thus be relatively uncommon. AIMS: To evaluate the prevalence of coeliac disease in elderly people. METHODS: The study comprised 2815 individuals aged 52-74 years. Clinical cases of coeliac disease were recorded. Sera from all subjects were screened by IgA class tissue transglutaminase antibodies, and seropositive underwent small bowel biopsy. RESULTS: Coeliac disease was detected in altogether 60 individuals, in 25 (0.89%) on clinical grounds, and screening found in 35 (1.24%) new biopsy-proven cases. Thus, a total prevalence of 2.13% (95% confidence intervals 1.60-2.67%) was reached. Of the screen-detected cases, 15 had symptoms, albeit mostly mild. Two out of the 60 had small bowel T-cell lymphoma and two had gastric cancer. The total frequency of biopsy-proven coeliac disease and seropositive cases without histological confirmation was 2.45% (1.88-3.02%). CONCLUSION: The prevalence of coeliac disease in elderly people was higher than what has been reported in the population in general. Active case finding by serologic screening is encouraged, since undetected cases may be prone to increased morbidity and mortality.
BACKGROUND: Up to 1% of the population suffer from coeliac disease. Data on the prevalence in elderly people is scant. We hypothesized that they would over time have developed obvious symptoms. Clinically silent or undiagnosed disease would thus be relatively uncommon. AIMS: To evaluate the prevalence of coeliac disease in elderly people. METHODS: The study comprised 2815 individuals aged 52-74 years. Clinical cases of coeliac disease were recorded. Sera from all subjects were screened by IgA class tissue transglutaminase antibodies, and seropositive underwent small bowel biopsy. RESULTS:Coeliac disease was detected in altogether 60 individuals, in 25 (0.89%) on clinical grounds, and screening found in 35 (1.24%) new biopsy-proven cases. Thus, a total prevalence of 2.13% (95% confidence intervals 1.60-2.67%) was reached. Of the screen-detected cases, 15 had symptoms, albeit mostly mild. Two out of the 60 had small bowel T-cell lymphoma and two had gastric cancer. The total frequency of biopsy-proven coeliac disease and seropositive cases without histological confirmation was 2.45% (1.88-3.02%). CONCLUSION: The prevalence of coeliac disease in elderly people was higher than what has been reported in the population in general. Active case finding by serologic screening is encouraged, since undetected cases may be prone to increased morbidity and mortality.
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Authors: Wolfgang Kratzer; Monika Kibele; Atilla Akinli; Marc Porzner; Bernhard O Boehm; Wolfgang Koenig; Suemeyra Oeztuerk; Richard A Mason; Ren Mao; Mark H Haenle Journal: World J Gastroenterol Date: 2013-05-07 Impact factor: 5.742
Authors: Lucas Malta Almeida; Luiz Claudio Castro; Rosa Harumi Uenishi; Fernanda Coutinho de Almeida; Patricia Maria Fritsch; Lenora Gandolfi; Riccardo Pratesi; Yanna Karla de Medeiros Nóbrega Journal: World J Gastroenterol Date: 2013-03-28 Impact factor: 5.742
Authors: Anitta Vilppula; Katri Kaukinen; Liisa Luostarinen; Ilkka Krekelä; Heikki Patrikainen; Raisa Valve; Markku Mäki; Pekka Collin Journal: BMC Gastroenterol Date: 2009-06-29 Impact factor: 3.067