Literature DB >> 1846707

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

A V Smrcka1, J R Hepler, K O Brown, P C Sternweis.   

Abstract

The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP3) and 1,2-diacylglycerol. This activity is regulated by a variety of hormones through G protein pathways. However, the specific G protein or proteins involved has not been identified. The alpha subunit of a newly discovered pertussis toxin-insensitive G protein (Gq) has recently been isolated and is now shown to stimulate the activity of polyphosphoinositide-specific phospholipase C (PI-PLC) from bovine brain. Both the maximal activity and the affinity of PI-PLC for calcium ion were affected. These results identify Gq as a G protein that regulates PI-PLC.

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Year:  1991        PMID： 1846707     DOI： 10.1126/science.1846707

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  181 in total

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Journal:  Plant Physiol       Date:  1993-05       Impact factor: 8.340

5.  Stomatal Opening Is Induced in Epidermal Peels of Commelina communis L. by GTP Analogs or Pertussis Toxin.

Authors:  H. J. Lee; E. B. Tucker; R. C. Crain; Y. Lee
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6.  Xenopus Gq alpha subunit activates the phosphatidylinositol pathway in Xenopus oocytes but does not consistently induce oocyte maturation.

Authors:  K L Guttridge; L D Smith; R Miledi
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Review 7.  G-protein signaling: back to the future.

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Journal:  Cell Mol Life Sci       Date:  2005-03       Impact factor: 9.261

8.  Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval.

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9.  Muscarinic regulation of cytosolic free calcium in canine tracheal smooth muscle cells: Ca2+ requirement for phospholipase C activation.

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10.  G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

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