OBJECTIVE: The aim of this study is to evaluate the correlation between brain perfusion and cognitive dysfunction in spinocerebellar ataxia type 6 (SCA6) patients. METHODS: Thirteen genetically confirmed SCA6 patients and 21 age- and education-matched control subjects were subjected to single photon emission computed tomography (SPECT) and neuropsychological tests. Brain perfusion was examined with SPECT analysis, while general cognition, verbal and visual memory, attention, visuospatial ability, language, executive function, depression, and anxiety were examined with the neuropsychological tests. RESULTS: SCA6 patients showed prefrontal hypoperfusion, and impairments of visual memory, verbal fluency, and executive function compared to control subjects. These neuropsychological impairments in SCA6 patients were significantly correlated with a decrease in prefrontal perfusion. This relation was not correlated to other factors, such as age, education and severity of cerebellar ataxia, which are possible relevant factors associated with cognitive performance. CONCLUSIONS: SCA6 patients have mild cognitive impairment, and correlating prefrontal hypoperfusion. These results indicate cognitive impairment in SCA6 patients resulting from prefrontal hypoperfusion.
OBJECTIVE: The aim of this study is to evaluate the correlation between brain perfusion and cognitive dysfunction in spinocerebellar ataxia type 6 (SCA6) patients. METHODS: Thirteen genetically confirmed SCA6patients and 21 age- and education-matched control subjects were subjected to single photon emission computed tomography (SPECT) and neuropsychological tests. Brain perfusion was examined with SPECT analysis, while general cognition, verbal and visual memory, attention, visuospatial ability, language, executive function, depression, and anxiety were examined with the neuropsychological tests. RESULTS:SCA6patients showed prefrontal hypoperfusion, and impairments of visual memory, verbal fluency, and executive function compared to control subjects. These neuropsychological impairments in SCA6patients were significantly correlated with a decrease in prefrontal perfusion. This relation was not correlated to other factors, such as age, education and severity of cerebellar ataxia, which are possible relevant factors associated with cognitive performance. CONCLUSIONS:SCA6patients have mild cognitive impairment, and correlating prefrontal hypoperfusion. These results indicate cognitive impairment in SCA6patients resulting from prefrontal hypoperfusion.
Authors: Martin Bares; Ovidiu V Lungu; Tao Liu; Tobias Waechter; Christopher M Gomez; James Ashe Journal: Cerebellum Date: 2011-06 Impact factor: 3.847
Authors: Licia Pereira; Raag D Airan; Ann Fishman; Jay J Pillai; Kalyani Kansal; Chiadi U Onyike; Jerry L Prince; Sarah H Ying; Haris I Sair Journal: Hum Brain Mapp Date: 2017-03-15 Impact factor: 5.038
Authors: Ina Klinke; Martina Minnerop; Tanja Schmitz-Hübsch; Marc Hendriks; Thomas Klockgether; Ullrich Wüllner; Christoph Helmstaedter Journal: Cerebellum Date: 2010-09 Impact factor: 3.847
Authors: Freya E Cooper; Manon Grube; Katharina Von Kriegstein; Sukhbinder Kumar; Philip English; Thomas P Kelly; Patrick F Chinnery; Timothy D Griffiths Journal: Neuropsychologia Date: 2011-11-25 Impact factor: 3.139
Authors: Freya E Cooper; Manon Grube; Kelly J Elsegood; John L Welch; Thomas P Kelly; Patrick F Chinnery; Timothy D Griffiths Journal: Behav Neurol Date: 2010 Impact factor: 3.342
Authors: Carlos R Hernandez-Castillo; Victor Galvez; Roberto Mercadillo; Rosalinda Diaz; Aurelio Campos-Romo; Juan Fernandez-Ruiz Journal: PLoS One Date: 2015-08-11 Impact factor: 3.240