Literature DB >> 18466765

Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential.

Jun-Ping Wen1, Wen-Shan Lv, Jun Yang, Ai-Fang Nie, Xiao-Bing Cheng, Ying Yang, Yan Ge, Xiao-Ying Li, Guang Ning.   

Abstract

Reproduction is accurately regulated by metabolic states in mammals. Adiponectin regulates luteinizing hormone (LH) secretion in the pituitary and energy homeostasis in the hypothalamus. We further investigated the gonadotropin-releasing hormone (GnRH) secretion regulation by adiponectin and its related molecular and electrophysiological mechanisms. The results showed that adiponectin receptors (AdipR1 and 2) were expressed in GT1-7 cells derived from hypothalamus neurons. GnRH secretion was inhibited via activation of AMP-activated protein kinase (AMPK). Moreover, we revealed that hyperpolarization of plasma membrane potentials and reduction of calcium influx was also caused by adiponectin.

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Year:  2008        PMID： 18466765     DOI： 10.1016/j.bbrc.2008.04.146

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  33 in total

Review 1.  The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction.

Authors:  Konstantinos G Michalakis; James H Segars
Journal:  Fertil Steril       Date:  2010-06-19       Impact factor: 7.329

2.  Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat.

Authors:  P K Shrestha; K P Briski
Journal:  Neuroscience       Date:  2015-04-28       Impact factor: 3.590

3.  Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.

Authors:  Ulrike Klenke; Carol Taylor-Burds; Susan Wray
Journal:  Endocrinology       Date:  2014-02-24       Impact factor: 4.736

4.  Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus.

Authors:  Jun-Ping Wen; Chun-e Liu; Ya-Ting Hu; Gang Chen; Li-xiang Lin
Journal:  Mol Cell Biochem       Date:  2010-07-13       Impact factor: 3.396

5.  Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: effects of 5-thioglucose on A2 functional biomarker and AMPK activity.

Authors:  B A Ibrahim; K P Briski
Journal:  Neuroscience       Date:  2014-03-13       Impact factor: 3.590

6.  GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase.

Authors:  Xiao-Bing Cheng; Jun-Ping Wen; Jun Yang; Ying Yang; Guang Ning; Xiao-Ying Li
Journal:  Endocrine       Date:  2010-11-05       Impact factor: 3.633

7.  The influence of adiponectin on the transcriptomic profile of porcine luteal cells.

Authors:  Karol Szeszko; Nina Smolinska; Marta Kiezun; Kamil Dobrzyn; Anna Maleszka; Tadeusz Kaminski
Journal:  Funct Integr Genomics       Date:  2015-12-29       Impact factor: 3.410

Review 8.  Regulation of gonadotropin-releasing hormone neurons by glucose.

Authors:  Alison V Roland; Suzanne M Moenter
Journal:  Trends Endocrinol Metab       Date:  2011-08-18       Impact factor: 12.015

Review 9.  Implications of adiponectin in linking metabolism to testicular function.

Authors:  Luc J Martin
Journal:  Endocrine       Date:  2013-11-28       Impact factor: 3.633

Review 10.  Exercise, Training, and the Hypothalamic-Pituitary-Gonadal Axis in Men and Women.

Authors:  Natalia Cano Sokoloff; Madhusmita Misra; Kathryn E Ackerman
Journal:  Front Horm Res       Date:  2016-06-27       Impact factor: 2.606
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