Literature DB >> 18466113

Cancer therapy: staying current with AMPK.

David A Fruman1, Aimee L Edinger.   

Abstract

Does the LKB1-AMPK (AMP-activated protein kinase) pathway act to suppress tumorigenesis or to rescue cancer cells from metabolic collapse? New work from the Alessi laboratory in this issue of the Biochemical Journal shows conclusively that AMPK activators delay the growth of tumours that occur spontaneously in PTEN (phosphatase and tensin homologue deleted on chromosome 10) heterozygous mice.

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Year:  2008        PMID： 18466113     DOI： 10.1042/BJ20080823

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

Review 1.  Amino acid sensing and mTOR regulation: inside or out?

Authors:  Deborah C I Goberdhan; Margret H Ogmundsdóttir; Shubana Kazi; Bruno Reynolds; Shivanthy M Visvalingam; Clive Wilson; C A Richard Boyd
Journal:  Biochem Soc Trans       Date:  2009-02       Impact factor: 5.407

2.  A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.

Authors:  Jui-Ling Hsu; Shih-Ping Liu; Chia-Chung Lee; Lih-Ching Hsu; Yunn-Fang Ho; Hsu-Shan Huang; Jih-Hwa Guh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-07-09       Impact factor: 3.000

3.  Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

Authors:  Gregor Beuster; Kim Zarse; Christoph Kaleta; René Thierbach; Michael Kiehntopf; Pablo Steinberg; Stefan Schuster; Michael Ristow
Journal:  J Biol Chem       Date:  2011-05-03       Impact factor: 5.157

4.  Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer.

Authors:  Marie-Claude Beauchamp; Amber Yasmeen; Ariane Knafo; Walter H Gotlieb
Journal:  J Oncol       Date:  2010-01-05       Impact factor: 4.375

5.  Metabolic shifts induced by fatty acid synthase inhibitor orlistat in non-small cell lung carcinoma cells provide novel pharmacodynamic biomarkers for positron emission tomography and magnetic resonance spectroscopy.

Authors:  Madhuri Sankaranarayanapillai; Nianxiang Zhang; Keith A Baggerly; Juri G Gelovani
Journal:  Mol Imaging Biol       Date:  2013-04       Impact factor: 3.488

6.  Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.

Authors:  Sung-Yun Cho; Hyo-Jeong Lee; Hyo-Jung Lee; Deok-Beom Jung; Hyunseok Kim; Eun Jung Sohn; Bonglee Kim; Ji Hoon Jung; Byoung-Mog Kwon; Sung-Hoon Kim
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-26       Impact factor: 2.629

7.  Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells.

Authors:  Jie Tang; Junjun Li; Guqing Zeng; Yanxiang Tang; Wenfang Tian; Jie He; J Philippe York; Xuefeng Xia
Journal:  J Ovarian Res       Date:  2013-10-08       Impact factor: 4.234

8.  Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling.

Authors:  Hong-tao Song; Yu Qin; Guo-dong Yao; Zhen-nan Tian; Song-bin Fu; Jing-shu Geng
Journal:  Mediators Inflamm       Date:  2014-04-16       Impact factor: 4.711
  8 in total

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