| Literature DB >> 18465957 |
Matthew V Schulmerich1, Jacqueline H Cole, Kathryn A Dooley, Michael D Morris, Jaclynn M Kreider, Steven A Goldstein.
Abstract
The effect of optical clearing with glycerol on the Raman spectra of bone tissue acquired transcutaneously on right and left tibiae from four mice is studied. Multiple transcutaneous measurements are obtained from each limb; glycerol is then applied as an optical clearing agent, and additional transcutaneous measurements are taken. Glycerol reduces the noise in the raw spectra (p=0.0037) and significantly improves the cross-correlation between the recovered bone factor and the exposed bone measurement in a low signal-to-noise region of the bone spectra (p=0.0245).Entities:
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Year: 2008 PMID: 18465957 PMCID: PMC2823071 DOI: 10.1117/1.2892687
Source DB: PubMed Journal: J Biomed Opt ISSN: 1083-3668 Impact factor: 3.170