The 5-HT7 receptor: a target for novel therapeutic avenues?

The 5-HT7 receptor is currently receiving widespread attention, and growing efforts are being made to understand its physiological/ pathophysiological significance. Evidence has accumulated which suggests that this receptor is involved in the regulation of limbic processes, circadian rhythm and sensory processing. Interest in the 5-HT7 receptor may increase further as new findings suggest its implication in the pathogenesis of migraine and the modulation of sympathetic afferent pathways. At this stage, however, the involvement of this receptor in human pathology and therapeutics can only be inferred. This review discusses the current knowledge of the 5-HT7 receptor in terms of its characteristics, and potential physiological and/or pathophysiological relevance. A brief overview of some high-affinity 5-HT7 receptor ligands, some of which are currently used as therapeutics, is also provided.