Literature DB >> 1846541

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE.

M Kan1, G H Zhang, R Zarnegar, G Michalopoulos, Y Myoken, W L McKeehan, J I Stevens.   

Abstract

Hepatocyte growth factor/hepatopoietin A is a mitogen for primary hepatocytes and may mediate regeneration after liver damage. To date, the activity of this novel factor has been restricted to hepatocytes. We now show that the factor is also a mitogen for a number of primary epithelial cells but is inactive with human foreskin fibroblasts, human endothelial cells and HEP3B cells. The factor also substitutes for HBGF-2 (basic FGF) in stimulating the anchorage-independent growth of SV-40 transformed rat kidney epithelial cells. Therefore, hepatocyte growth factor/hepatopoietin A appears to act on a variety of epithelial, but not mesenchymal, cells which respond to HBGFs.

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Year:  1991        PMID： 1846541     DOI： 10.1016/0006-291x(91)90524-b

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  58 in total

1.  The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.

Authors:  C R Maroun; M Holgado-Madruga; I Royal; M A Naujokas; T M Fournier; A J Wong; M Park
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

2.  The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.

Authors:  C R Maroun; M A Naujokas; M Holgado-Madruga; A J Wong; M Park
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

3.  Hepatocyte growth factor.

Authors:  A J Strain; J M Neuberger
Journal:  Gut       Date:  1992-02       Impact factor: 23.059

Review 4.  Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis.

Authors:  Okkyung Rho; Dae Joon Kim; Karou Kiguchi; John Digiovanni
Journal:  Mol Carcinog       Date:  2010-07-20       Impact factor: 4.784

5.  Activating mutations for the met tyrosine kinase receptor in human cancer.

Authors:  M Jeffers; L Schmidt; N Nakaigawa; C P Webb; G Weirich; T Kishida; B Zbar; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

6.  Uptake and distribution of hepatocyte growth factor in normal and regenerating adult rat liver.

Authors:  M L Liu; W M Mars; R Zarnegar; G K Michalopoulos
Journal:  Am J Pathol       Date:  1994-01       Impact factor: 4.307

7.  Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.

Authors:  J J Maher
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

8.  Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during embryonic development; studies by in situ hybridisation and northern blot analysis.

Authors:  Y Wang; C Selden; S Farnaud; D Calnan; H J Hodgson
Journal:  J Anat       Date:  1994-12       Impact factor: 2.610

9.  Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

Authors:  R J Panos; J S Rubin; K G Csaky; S A Aaronson; R J Mason
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

10.  A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.

Authors:  C Ponzetto; A Bardelli; F Maina; P Longati; G Panayotou; R Dhand; M D Waterfield; P M Comoglio
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272
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