Literature DB >> 1846521

Insulin rapidly increases glycerol-3-phosphate-acyltransferase activity in rat adipocytes.

M C Vila1, R V Farese.   

Abstract

Glycerol-3-phosphate acyltransferase (G3PAT) was activated by insulin in intact rat adipocytes within 1 min: this activation persisted for 10 min, and was due to a decrease in the Km of the enzyme. The addition of insulin to control adipocyte membranes also increased G3PAT activity, and this effect was mimicked by phosphatidylinositol-specific phospholipase C. Cytosol fractions from insulin-treated adipocytes stimulated G3PAT activity of control membranes, suggesting that a soluble mediator is released during insulin action, possibly through activation of a PI-specific PLC.

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Year:  1991        PMID： 1846521     DOI： 10.1016/0003-9861(91)90309-7

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  8 in total

1.  A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase.

Authors:  T E Lau; M A Rodriguez
Journal:  Lipids       Date:  1996-03       Impact factor: 1.880

2.  GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.

Authors:  Dandan Shan; Jian-liang Li; Leeying Wu; Dongmei Li; Jonathan Hurov; James F Tobin; Ruth E Gimeno; Jingsong Cao
Journal:  J Lipid Res       Date:  2010-02-24       Impact factor: 5.922

3.  AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

Authors:  D M Muoio; K Seefeld; L A Witters; R A Coleman
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

4.  Effects of adrenaline on triacylglycerol synthesis and turnover in ventricular myocytes from adult rats.

Authors:  E M Swanton; E D Saggerson
Journal:  Biochem J       Date:  1997-12-15       Impact factor: 3.857

5.  Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats.

Authors:  R V Farese; M L Standaert; K Yamada; L C Huang; C Zhang; D R Cooper; Z Wang; Y Yang; S Suzuki; T Toyota
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

Review 6.  Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.

Authors:  Angela A Wendel; Tal M Lewin; Rosalind A Coleman
Journal:  Biochim Biophys Acta       Date:  2008-11-07

7.  ACTH stimulates the release of alkaline phosphatase through Gi-mediated activation of a phospholipase C and the release of inositol-phosphoglycan.

Authors:  Claudia N Martini; Silvia G Vaena de Avalos; María del Carmen Vila
Journal:  Mol Cell Biochem       Date:  2004-03       Impact factor: 3.396

8.  The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes.

Authors:  M L Standaert; A Avignon; K Yamada; G Bandyopadhyay; R V Farese
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857
  8 in total

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