Literature DB >> 1846503

Mechanism of inhibition of HSV-1 replication by tumor necrosis factor and interferon gamma.

E Feduchi1, L Carrasco.   

Abstract

Tumor necrosis factor (TNF) synergizes with interferon (IFN gamma) in the blockade of HSV-1 replication. Antibodies against IFN beta block this synergism, implying a role of IFN beta in the antiviral activity of TNF plus IFN gamma. IFN beta 1 added exogenously to Hep-2 cells shows antiviral activity against HSV-1 only at high concentrations, whereas IFN beta 2 (also known as IL-6) alone has no effect on the replication of VSV or HSV-1 even when 1,000 U/ml are present. Our results are in accordance with the idea that TNF induces IFN beta 1 and that both cytokines must be present in the culture medium to synergize with IFN gamma in order to inhibit HSV-1 replication.

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Year:  1991        PMID： 1846503     DOI： 10.1016/0042-6822(91)90100-p

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  13 in total

1.  Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells.

Authors:  P Monini; F Carlini; M Stürzl; P Rimessi; F Superti; M Franco; G Melucci-Vigo; A Cafaro; D Goletti; C Sgadari; S Butto'; P Leone; C Chiozzini; C Barresi; A Tinari; A Bonaccorsi; M R Capobianchi; M Giuliani; A di Carlo; M Andreoni; G Rezza; B Ensoli
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

Review 2.  Experimental investigation of herpes simplex virus latency.

Authors:  E K Wagner; D C Bloom
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

Review 3.  Cordelia, Goneril and the febrile response.

Authors:  P A Mackowiak
Journal:  Trans Am Clin Climatol Assoc       Date:  1997

4.  Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils.

Authors:  Derek J Royer; Min Zheng; Christopher D Conrady; Daniel J J Carr
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-06       Impact factor: 4.799

5.  Roles of M1 and M2 Macrophages in Herpes Simplex Virus 1 Infectivity.

Authors:  Dhong Hyun Lee; Homayon Ghiasi
Journal:  J Virol       Date:  2017-07-12       Impact factor: 5.103

6.  Influenza A virus replication is inhibited by tumor necrosis factor-alpha in vitro.

Authors:  H Van Campen
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

7.  Role of the nitric oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia prowazekii strains in L929 cells treated with tumor necrosis factor alpha and gamma interferon.

Authors:  J Turco; H H Winkler
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

8.  Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection.

Authors:  T Liu; Q Tang; R L Hendricks
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

9.  Human peripheral blood CD4+ and CD8+ T cells express Th1-like cytokine mRNA and proteins following in vitro stimulation with heat-inactivated Brucella abortus.

Authors:  M B Zaitseva; H Golding; M Betts; A Yamauchi; E T Bloom; L E Butler; L Stevan; B Golding
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441

10.  Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity.

Authors:  Xianting Ding; David Jesse Sanchez; Arash Shahangian; Ibrahim Al-Shyoukh; Genhong Cheng; Chih-Ming Ho
Journal:  Int J Nanomedicine       Date:  2012-05-10
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