BACKGROUND: Glycosylated hemoglobin (HbA1c) level on admission is a prognostic factor for mortality in patients with and without diabetes after myocardial infarction. In the present study, the authors examined the relationship between admission HbA1c level and myocardial perfusion abnormalities in patients with acute myocardial infarction. METHODS: One hundred consecutive patients with acute myocardial infarction who were treated with thrombolytic therapy were included in the present prospective study. Blood glucose and HbA1c levels of all patients were measured within 3 h of admission. Patients were divided into three groups according to HbA1c level: 4.5% to 6.4% (n=25), 6.5% to 8.5% (n=28) and higher than 8.5% (n=47). All patients then underwent exercise thallium-201 imaging and coronary angiography to determine ischemic scores and the number of diseased coronary arteries four weeks after admission. RESULTS: Seven patients died within the four-week follow-up period. There was a significant relationship between admission HbA1c level and mortality (P=0.009). Furthermore, there was a significant relationship between HbA1c level and total ischemic scores in patients with acute myocardial infarction (r=0.482; P=0.001). Ischemic scores increased as HbA1c levels increased in patients with acute myocardial infarction. CONCLUSIONS: The results demonstrated that admission plasma glucose and HbA1c levels are prognostic factors associated with mortality after acute myocardial infarction.
BACKGROUND: Glycosylated hemoglobin (HbA1c) level on admission is a prognostic factor for mortality in patients with and without diabetes after myocardial infarction. In the present study, the authors examined the relationship between admission HbA1c level and myocardial perfusion abnormalities in patients with acute myocardial infarction. METHODS: One hundred consecutive patients with acute myocardial infarction who were treated with thrombolytic therapy were included in the present prospective study. Blood glucose and HbA1c levels of all patients were measured within 3 h of admission. Patients were divided into three groups according to HbA1c level: 4.5% to 6.4% (n=25), 6.5% to 8.5% (n=28) and higher than 8.5% (n=47). All patients then underwent exercise thallium-201 imaging and coronary angiography to determine ischemic scores and the number of diseased coronary arteries four weeks after admission. RESULTS: Seven patients died within the four-week follow-up period. There was a significant relationship between admission HbA1c level and mortality (P=0.009). Furthermore, there was a significant relationship between HbA1c level and total ischemic scores in patients with acute myocardial infarction (r=0.482; P=0.001). Ischemic scores increased as HbA1c levels increased in patients with acute myocardial infarction. CONCLUSIONS: The results demonstrated that admission plasma glucose and HbA1c levels are prognostic factors associated with mortality after acute myocardial infarction.
Authors: Jorik R Timmer; Jan Paul Ottervanger; Menko-Jan de Boer; Jan-Henk E Dambrink; Jan C A Hoorntje; A T Marcel Gosselink; Harry Suryapranata; Felix Zijlstra; Arnoud W J van 't Hof Journal: J Am Coll Cardiol Date: 2005-04-05 Impact factor: 24.094
Authors: Nazneem N Wahab; Elizabeth A Cowden; Neil J Pearce; Martin J Gardner; Heather Merry; Jafna L Cox Journal: J Am Coll Cardiol Date: 2002-11-20 Impact factor: 24.094
Authors: David Vivas; Juan C García-Rubira; Esther Bernardo; Dominick J Angiolillo; Patricia Martín; Alfonso Calle-Pascual; Iván Núñez-Gil; Carlos Macaya; Antonio Fernández-Ortiz Journal: J Thromb Thrombolysis Date: 2013-02 Impact factor: 2.300
Authors: Gong Su; Shu-hua Mi; Hong Tao; Zhao Li; Hong-Xia Yang; Hong Zheng; Yun Zhou; Lei Tian Journal: Diabetes Care Date: 2013-01-24 Impact factor: 19.112