Literature DB >> 18464090

Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level.

Feng Zhao1, En-Qi He, Lu Wang, Ke Liu.   

Abstract

Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most sensitive cell line among the cell lines screened) via the activation of caspase 3, up-regulation of bax, and down-regulation of bcl-2. Furthermore, its inhibitory activity on the level of vascular endothelial growth factor was also verified by ELISA.

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Year:  2008        PMID： 18464090     DOI： 10.1080/10286020801948334

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  18 in total

1.  Investigation of the potential anticancer effects of napelline and talatisamine dirterpenes on experimental brain tumor models.

Authors:  Merve Demirbağ Karaali; Elanur Aydın Karataş
Journal:  Cytotechnology       Date:  2020-06-11       Impact factor: 2.058

2.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

3.  Andrographolide regulates epidermal growth factor receptor and transferrin receptor trafficking in epidermoid carcinoma (A-431) cells.

Authors:  Y Tan; K H Chiow; D Huang; S H Wong
Journal:  Br J Pharmacol       Date:  2010-02-19       Impact factor: 8.739

4.  Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata.

Authors:  Shuo Yang; Andrew M Evens; Sheila Prachand; Amareshwar T K Singh; Savita Bhalla; Kevin David; Leo I Gordon
Journal:  Clin Cancer Res       Date:  2010-08-26       Impact factor: 12.531

5.  Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.

Authors:  Yulin Ren; A Douglas Kinghorn
Journal:  J Med Chem       Date:  2020-12-08       Impact factor: 7.446

6.  Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas.

Authors:  Yu-Tang Tung; Hsiao-Ling Chen; Hsin-Chung Tsai; Shang-Hsun Yang; Yi-Chun Chang; Chuan-Mu Chen
Journal:  Evid Based Complement Alternat Med       Date:  2013-08-20       Impact factor: 2.629

7.  Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo.

Authors:  Nawal Al-Henhena; Rozaida Poh Yuen Ying; Salmah Ismail; Walaa Najm; Wala Najm; Shaden A M Khalifa; Hesham El-Seedi; Mahmood Ameen Abdulla; Mahmood Ameen Abdulla
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

8.  Tinospora cordifolia: One plant, many roles.

Authors:  Soham Saha; Shyamasree Ghosh
Journal:  Anc Sci Life       Date:  2012-04

9.  Andrographolide: a new plant-derived antineoplastic entity on horizon.

Authors:  Astha Varma; Harish Padh; Neeta Shrivastava
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-10       Impact factor: 2.629

10.  Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.

Authors:  Shih-Hung Yang; Seu-Mei Wang; Jhih-Pu Syu; Ying Chen; Sheng-De Wang; Yu-Sen Peng; Meng-Fai Kuo; Hsiu-Ni Kung
Journal:  Biomed Res Int       Date:  2014-08-05       Impact factor: 3.411
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