| Literature DB >> 18463966 |
Satoshi Hashino1, Sumiko Kobayashi, Mutsumi Takahata, Masahiro Onozawa, Masao Nakagawa, Takahito Kawamura, Fumie Fujisawa, Koh Izumiyama, Kaoru Kahata, Takeshi Kondo, Masahiro Asaka.
Abstract
A 27-year-old man with advanced colon cancer that was resistant to conventional chemoradiotherapies was treated with reduced-intensity allogeneic peripheral blood stem cell transplantation (PBSCT). After obtaining complete donor-type chimerism, there was an apparent graft-versus-tumor effect accompanied by severe hepatic graft-versus-host disease (GVHD) showing hyperbilirubinemia, resulting in a stable disease condition that lasted for 18 months, which had not been seen previously in his previous disease history. The antitumor effect observed in this patient was insufficient for the patient to achieve complete remission, because the disease was at an already widespread and treatment-resistant stage. He finally died of hepatic failure due to extensive liver GVHD 65 months after the diagnosis of the advanced colon cancer and 29 months after the allogeneic PBSCT. Prospective studies are necessary to achieve better clinical results in patients with advanced colon cancer.Entities:
Mesh：
Year: 2008 PMID： 18463966 DOI： 10.1007/s10147-007-0716-4
Source DB: PubMed Journal: Int J Clin Oncol ISSN： 1341-9625 Impact factor: 3.402