Literature DB >> 18462843

Safety of MF59 adjuvant.

Viola Schultze1, Vicente D'Agosto, Andreas Wack, Deborah Novicki, Juergen Zorn, Renald Hennig.   

Abstract

The need to enhance the immunogenicity of purified subunit antigens has prompted the development of new adjuvants. The adjuvant emulsion MF59 has been tested in animals in combination with different antigens and finally evaluated in humans. It was licensed after the successful outcome of preclinical and clinical testing. This paper summarizes the main characteristics of the MF59 adjuvant, including animal testing, clinical experience with various vaccines, and information from current postmarketing surveillance data. This review supports the hypothesis that MF59 is a safe adjuvant for human use.

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Year:  2008        PMID： 18462843     DOI： 10.1016/j.vaccine.2008.03.093

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  49 in total

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5.  A phase II study of an investigational tetravalent influenza vaccine formulation combining MF59®: adjuvanted, pre-pandemic, A/H5N1 vaccine and trivalent seasonal influenza vaccine in healthy adults.

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Review 6.  Current prospects and future challenges for nasal vaccine delivery.

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Journal:  Hum Vaccin Immunother       Date:  2016-12-09       Impact factor: 3.452

7.  Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein.

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Journal:  Vaccine       Date:  2012-02-22       Impact factor: 3.641

Review 8.  Cross-protection against drifted influenza viruses: options offered by adjuvanted and intradermal vaccines.

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Journal:  Hum Vaccin Immunother       Date:  2013-01-07       Impact factor: 3.452

9.  Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.

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Journal:  PLoS One       Date:  2009-09-16       Impact factor: 3.240

10.  Emulsified nanoparticles containing inactivated influenza virus and CpG oligodeoxynucleotides critically influences the host immune responses in mice.

Authors:  Ming-Hsi Huang; Su-Chen Lin; Chia-Hsin Hsiao; Hsin-Ju Chao; Hung-Ren Yang; Chien-Chun Liao; Po-Wei Chuang; Huang-Pi Wu; Chiung-Yi Huang; Chih-Hsiang Leng; Shih-Jen Liu; Hsin-Wei Chen; Ai-Hsiang Chou; Alan Yung-Chih Hu; Pele Chong
Journal:  PLoS One       Date:  2010-08-19       Impact factor: 3.240
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