Literature DB >> 18462726

Using recombinant activated factor VII, B-Lynch compression, and reversible embolization of the uterine arteries for treatment of severe conservatively intractable postpartum hemorrhage: new method for management of massive hemorrhage in cases of placenta increta.

Sylvia Mechsner1, Kaven Baessler, Bergit Brunne, Thomas Albrecht, Hartmut Hopp, Joachim W Dudenhausen.   

Abstract

OBJECTIVE: To investigate a new method for management of massive postpartum hemorrhage in cases of abnormal placenta adhesion.
DESIGN: Case report.
SETTING: University hospital. PATIENT(S): An 18-year-old nullipara presented with fulminant postpartum bleeding after cesarean section due to placenta increta. The patient developed hemorrhagic and septic shock associated with disseminated intravascular coagulation. INTERVENTION(S): Treatment with uterotonic drugs like oxytocin and prostaglandins and conservative procedures like transfusion of packed red cells and fresh frozen plasma failed to control the diffuse bleeding. Further intervention consisted of B-Lynch sutures, recombinant activated factor VII, and reversible embolization of the uterine arteries. RESULT(S): The bleeding stopped after operative B-Lynch compression and recombinant activated factor VII. In the interval, the bleeding continued under therapeutically resistant disseminated intravascular coagulation, and finally bilateral reversible embolization of the uterine arteries was performed to avoid an emergency hysterectomy to preserve fertility in this young woman. CONCLUSION(S): This is a case of abnormal placenta adhesion with massive postpartum hemorrhage in which different conservative and operative treatments were combined to avoid a hysterectomy with loss of fertility and major psychological impact for the young mother.

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Year:  2008        PMID: 18462726     DOI: 10.1016/j.fertnstert.2007.12.057

Source DB:  PubMed          Journal:  Fertil Steril        ISSN: 0015-0282            Impact factor:   7.329


  2 in total

1.  Recombinant activated factor VII (rFVIIa/NovoSeven®) in the management of severe postpartum haemorrhage: initial report of a multicentre case series in Japan.

Authors:  Takao Kobayashi; Masao Nakabayashi; Akira Yoshioka; Makoto Maeda; Tsuyomu Ikenoue
Journal:  Int J Hematol       Date:  2011-12-09       Impact factor: 2.490

Review 2.  Endovascular interventional modalities for haemorrhage control in abnormal placental implantation deliveries: a systematic review and meta-analysis.

Authors:  Yousef Shahin; Chun Lap Pang
Journal:  Eur Radiol       Date:  2018-02-05       Impact factor: 5.315

  2 in total

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