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Literature DB >> 1846229

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.

D M Papazian¹, L C Timpe, Y N Jan, L Y Jan.

Abstract

Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.

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Year: 1991 PMID： 1846229 DOI： 10.1038/349305a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

180 in total

1. The pore of plant K(+) channels is involved in voltage and pH sensing: domain-swapping between different K(+) channel alpha-subunits.

Authors: S Hoth; D Geiger; D Becker; R Hedrich
Journal: Plant Cell Date: 2001-04 Impact factor: 11.277

9. Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of L-type calcium channels.

Authors: H Yamaguchi; J N Muth; M Varadi; A Schwartz; G Varadi
Journal: Proc Natl Acad Sci U S A Date: 1999-02-16 Impact factor: 11.205

10. Divalent cations selectively alter the voltage dependence of inactivation of A-currents in chick autonomic neurons.

Authors: M E Wisgirda; S E Dryer
Journal: Pflugers Arch Date: 1993-06 Impact factor: 3.657

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.

1. The pore of plant K(+) channels is involved in voltage and pH sensing: domain-swapping between different K(+) channel alpha-subunits.

2. Role of transmembrane segment S5 on gating of voltage-dependent K+ channels.

3. Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment.

4. Allosteric gating of a large conductance Ca-activated K+ channel.

5. Gating currents from a delayed rectifier K+ channel with altered pore structure and function.

6. Involvement of different S4 parts in the voltage dependency of Na channel gating.

7. Electrostatic model of S4 motion in voltage-gated ion channels.

8. Initial response of the potassium channel voltage sensor to a transmembrane potential.

9. Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of L-type calcium channels.

10. Divalent cations selectively alter the voltage dependence of inactivation of A-currents in chick autonomic neurons.