Literature DB >> 18461271

Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans.

Vittorio Coiro1, Gloria Saccani-Jotti, Pasquale Rubino, Guido Manfredi, Paola Vacca, Elio Volta, Paolo Chiodera.   

Abstract

UNLABELLED: Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. TESTS: ghrelin (1 microg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.

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Year:  2008        PMID： 18461271     DOI： 10.1007/s00702-008-0057-0

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

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Authors:  P Chiodera; R Volpi; L Capretti; V Coiro
Journal:  Clin Endocrinol (Oxf)       Date:  2001-01       Impact factor: 3.478

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5.  Effects of ghrelin on circulating neuropeptide Y levels in humans.

Authors:  Vittorio Coiro; Gloria Saccani-Jotti; Pasquale Rubino; Guido Manfredi; Andrea Melani; Paolo Chiodera
Journal:  Neuro Endocrinol Lett       Date:  2006-12       Impact factor: 0.765

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Review 7.  Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor.

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Journal:  Clin Endocrinol (Oxf)       Date:  2005-01       Impact factor: 3.478

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Journal:  Endocr Rev       Date:  1999-02       Impact factor: 19.871

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Authors:  R Arletti; A Benelli; A Bertolini
Journal:  Peptides       Date:  1989 Jan-Feb       Impact factor: 3.750

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Authors:  J M Pavia; J A Hastings; M J Morris
Journal:  Brain Res       Date:  1995-08-28       Impact factor: 3.252
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  4 in total

1.  Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization.

Authors:  Paul J Currie; Christine D Coiro; Raya Duenas; Janet L Guss; Aaisha Mirza; Neta Tal
Journal:  Brain Res       Date:  2011-04-18       Impact factor: 3.252

Review 2.  Clinical review: The human experience with ghrelin administration.

Authors:  Margaret C Garin; Carrie M Burns; Shailja Kaul; Anne R Cappola
Journal:  J Clin Endocrinol Metab       Date:  2013-03-26       Impact factor: 5.958

Review 3.  Two ghrelin receptor agonists for adults with malnutrition: a systematic review and meta-analysis.

Authors:  Jianhua Su; Jin Geng; Jisheng Bao; Yin Tang; Menglan Liu; Haibin Yu; Yi Han; Wei Huang; Suming Zhou
Journal:  Nutr J       Date:  2016-11-16       Impact factor: 3.271

4.  Increased Ghrelin but Low Ghrelin-Reactive Immunoglobulins in a Rat Model of Methotrexate Chemotherapy-Induced Anorexia.

Authors:  Marie François; Kuniko Takagi; Romain Legrand; Nicolas Lucas; Stephanie Beutheu; Christine Bôle-Feysot; Aurore Cravezic; Naouel Tennoune; Jean-Claude do Rego; Moïse Coëffier; Akio Inui; Pierre Déchelotte; Sergueï O Fetissov
Journal:  Front Nutr       Date:  2016-07-26
  4 in total

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