CONTEXT: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. OBJECTIVE: Our objective was to evaluate whether assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. DESIGN: The Malmö Osteoporosis Prospective Risk Assessment study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3, and 5 yr. SETTING: We conducted a population-based study. PARTICIPANTS: Participants included 1044 women, all 75 yr old at baseline. MAIN OUTCOME MEASURES: Seven bone turnover markers were assessed at baseline and at 1, 3, and 5 yr (n = 573). The 5-yr change in areal bone mineral density (aBMD) was also determined. RESULTS: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-yr measurements was used (standardized regression coefficients -0.12 to -0.23, P < 0.01). Adding the 3-yr and 5-yr measurement further strengthened the correlation (regression coefficients up to -0.30, P < 0.001). Women with constantly high turnover lost significantly more bone at total body assessment (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, P for trend < 0.001). They also had a greater decrease in hip BMD (-8.3, -6.0, and -5.1%, respectively, P = 0.010). Results were similar also in the subgroup of women with osteopenia. CONCLUSIONS: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk.
CONTEXT: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. OBJECTIVE: Our objective was to evaluate whether assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. DESIGN: The Malmö Osteoporosis Prospective Risk Assessment study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3, and 5 yr. SETTING: We conducted a population-based study. PARTICIPANTS: Participants included 1044 women, all 75 yr old at baseline. MAIN OUTCOME MEASURES: Seven bone turnover markers were assessed at baseline and at 1, 3, and 5 yr (n = 573). The 5-yr change in areal bone mineral density (aBMD) was also determined. RESULTS: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-yr measurements was used (standardized regression coefficients -0.12 to -0.23, P < 0.01). Adding the 3-yr and 5-yr measurement further strengthened the correlation (regression coefficients up to -0.30, P < 0.001). Women with constantly high turnover lost significantly more bone at total body assessment (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, P for trend < 0.001). They also had a greater decrease in hip BMD (-8.3, -6.0, and -5.1%, respectively, P = 0.010). Results were similar also in the subgroup of women with osteopenia. CONCLUSIONS: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk.
Authors: Maria Swanberg; Fiona McGuigan; Kaisa K Ivaska; Paul Gerdhem; Ulf H Lerner; Richard Bucala; George Kuchel; Anne Kenny; Kristina Akesson Journal: Bone Date: 2010-05-12 Impact factor: 4.398
Authors: E A Marques; V Gudnason; T Lang; G Sigurdsson; S Sigurdsson; T Aspelund; K Siggeirsdottir; L Launer; G Eiriksdottir; T B Harris Journal: Osteoporos Int Date: 2016-06-24 Impact factor: 4.507
Authors: E Cavalier; P Bergmann; O Bruyère; P Delanaye; A Durnez; J-P Devogelaer; S L Ferrari; E Gielen; S Goemaere; J-M Kaufman; A Nzeusseu Toukap; J-Y Reginster; A-F Rousseau; S Rozenberg; A J Scheen; J-J Body Journal: Osteoporos Int Date: 2016-03-30 Impact factor: 4.507
Authors: J Nahas-Neto; L M Cangussu; C L Orsatti; F N Bueloni-Dias; P F Poloni; E B Schmitt; E A P Nahas Journal: Osteoporos Int Date: 2018-02-15 Impact factor: 4.507
Authors: L Idolazzi; M Rossini; O Viapiana; V Braga; A Fassio; C Benini; V Kunnathully; S Adami; D Gatti Journal: Osteoporos Int Date: 2016-06-01 Impact factor: 4.507