CONTEXT: In persons with impaired glucose tolerance (IGT), both impaired insulin secretion and insulin resistance contribute to the conversion to type 2 diabetes mellitus (T2DM). However, few studies have used criterion standard measures to asses the predictive value of impaired insulin secretion and insulin resistance for the conversion to T2DM in a Caucasian IGT population. OBJECTIVES: The objective of the study was to determine the predictive value of measures of insulin secretion and insulin resistance derived from a hyperglycemic clamp, including the disposition index, for the development of T2DM in a Caucasian IGT population. DESIGN, SETTING, AND PARTICIPANTS: The population-based Hoorn IGT study consisted of 101 Dutch IGT subjects (aged < 75 yr), with mean 2-h plasma glucose values, of two separate oral glucose tolerance tests, between 8.6 and 11.1 mmol/liter. A hyperglycemic clamp at baseline was performed to assess first-phase and second-phase insulin secretion and insulin sensitivity. During follow-up, conversion to T2DM was assessed by means of 6-monthly fasting glucose levels and yearly oral glucose tolerance tests. RESULTS: The cumulative incidence of T2DM was 34.7%. Hazard ratio for T2DM development adjusted for age, sex, and body mass index was 5.74 [95% confidence interval (CI) 2.60-12.67] for absence of first insulin peak, 1.58 (95% CI 0.60-4.17) for lowest vs. highest tertile of insulin sensitivity, and 1.78 (95% CI 0.65-4.88) for lowest vs. highest tertile of the disposition index. CONCLUSIONS: In these Caucasian persons with IGT, the absence of the first insulin peak was the strongest predictor of T2DM.
CONTEXT: In persons with impaired glucose tolerance (IGT), both impaired insulin secretion and insulin resistance contribute to the conversion to type 2 diabetes mellitus (T2DM). However, few studies have used criterion standard measures to asses the predictive value of impaired insulin secretion and insulin resistance for the conversion to T2DM in a Caucasian IGT population. OBJECTIVES: The objective of the study was to determine the predictive value of measures of insulin secretion and insulin resistance derived from a hyperglycemic clamp, including the disposition index, for the development of T2DM in a Caucasian IGT population. DESIGN, SETTING, AND PARTICIPANTS: The population-based Hoorn IGT study consisted of 101 Dutch IGT subjects (aged < 75 yr), with mean 2-h plasma glucose values, of two separate oral glucose tolerance tests, between 8.6 and 11.1 mmol/liter. A hyperglycemic clamp at baseline was performed to assess first-phase and second-phase insulin secretion and insulin sensitivity. During follow-up, conversion to T2DM was assessed by means of 6-monthly fasting glucose levels and yearly oral glucose tolerance tests. RESULTS: The cumulative incidence of T2DM was 34.7%. Hazard ratio for T2DM development adjusted for age, sex, and body mass index was 5.74 [95% confidence interval (CI) 2.60-12.67] for absence of first insulin peak, 1.58 (95% CI 0.60-4.17) for lowest vs. highest tertile of insulin sensitivity, and 1.78 (95% CI 0.65-4.88) for lowest vs. highest tertile of the disposition index. CONCLUSIONS: In these Caucasian persons with IGT, the absence of the first insulin peak was the strongest predictor of T2DM.
Authors: Tamara S Hannon; Steven E Kahn; Kristina M Utzschneider; Thomas A Buchanan; Kristen J Nadeau; Philip S Zeitler; David A Ehrmann; Silva A Arslanian; Sonia Caprio; Sharon L Edelstein; Peter J Savage; Kieren J Mather Journal: Diabetes Obes Metab Date: 2017-06-22 Impact factor: 6.577
Authors: Sophie J Bernelot Moens; Hans L Mooij; H Carlijne Hassing; Janine K Kruit; Julia J Witjes; Michiel A J van de Sande; Aart J Nederveen; Ding Xu; Geesje M Dallinga-Thie; Jeffrey D Esko; Erik S G Stroes; Max Nieuwdorp Journal: PLoS One Date: 2014-12-26 Impact factor: 3.240
Authors: Annemarie M Simonis-Bik; Giel Nijpels; Timon W van Haeften; Jeanine J Houwing-Duistermaat; Dorret I Boomsma; Erwin Reiling; Els C van Hove; Michaela Diamant; Mark H H Kramer; Robert J Heine; J Antonie Maassen; P Eline Slagboom; Gonneke Willemsen; Jacqueline M Dekker; Elisabeth M Eekhoff; Eco J de Geus; Leen M 't Hart Journal: Diabetes Date: 2009-10-15 Impact factor: 9.461
Authors: Carlos Lorenzo; Lynne E Wagenknecht; Ralph B D'Agostino; Marian J Rewers; Andrew J Karter; Steven M Haffner Journal: Diabetes Care Date: 2009-10-06 Impact factor: 19.112
Authors: Leen M 't Hart; Annemarie M Simonis-Bik; Giel Nijpels; Timon W van Haeften; Silke A Schäfer; Jeanine J Houwing-Duistermaat; Dorret I Boomsma; Marlous J Groenewoud; Erwin Reiling; Els C van Hove; Michaela Diamant; Mark H H Kramer; Robert J Heine; J Antonie Maassen; Kerstin Kirchhoff; Fausto Machicao; Hans-Ulrich Häring; P Eline Slagboom; Gonneke Willemsen; Elisabeth M Eekhoff; Eco J de Geus; Jacqueline M Dekker; Andreas Fritsche Journal: Diabetes Date: 2009-10-06 Impact factor: 9.461
Authors: Menno Vergeer; Liam R Brunham; Joris Koetsveld; Janine K Kruit; C Bruce Verchere; John J P Kastelein; Michael R Hayden; Erik S G Stroes Journal: Diabetes Care Date: 2010-01-12 Impact factor: 19.112