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Literature DB >> 18460286

Pathophysiology of restless legs syndrome: evidence for iron involvement.

Abstract

Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.

Entities: Chemical Disease

Mesh：

Substances：
Iron

Year: 2008 PMID： 18460286 DOI： 10.1007/s11910-008-0026-x

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

46 in total

1. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies.

Authors: N Turjanski; A J Lees; D J Brooks
Journal: Neurology Date: 1999-03-23 Impact factor: 9.910

2. Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels.

Authors: Jane C Dale; Mary F Burritt; Alan R Zinsmeister
Journal: Am J Clin Pathol Date: 2002-05 Impact factor: 2.493

3. Ferrokinetic circadian rhythm in normal subjects.

Authors: A O Carmena; H Portuondo; J Callejas; M E Alvarez
Journal: Haematologia (Budap) Date: 1976

4. Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions.

Authors: Z Ye; J R Connor
Journal: Nucleic Acids Res Date: 2000-04-15 Impact factor: 16.971

5. Iron deficiency alters dopamine transporter functioning in rat striatum.

Authors: K M Erikson; B C Jones; J L Beard
Journal: J Nutr Date: 2000-11 Impact factor: 4.798

6. Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3',5'-monophosphate.

Authors: M Tsutsumi; M K Skinner; E Sanders-Bush
Journal: J Biol Chem Date: 1989-06-05 Impact factor: 5.157

7. Neuropathology of primary restless leg syndrome: absence of specific tau- and alpha-synuclein pathology.

Authors: Sean J Pittock; Timothy Parrett; Charles H Adler; Joseph E Parisi; Dennis W Dickson; J Eric Ahlskog
Journal: Mov Disord Date: 2004-06 Impact factor: 10.338

8. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome.

Authors: Shen Qu; Weidong Le; Xiong Zhang; Wenjie Xie; Aijun Zhang; William G Ondo
Journal: J Neuropathol Exp Neurol Date: 2007-05 Impact factor: 3.685

9. Iron and the restless legs syndrome.

Authors: E R Sun; C A Chen; G Ho; C J Earley; R P Allen
Journal: Sleep Date: 1998-06-15 Impact factor: 5.849

10. Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain.

Authors: S L Clardy; X Wang; W Zhao; W Liu; G A Chase; J L Beard; B True Felt; J R Connor
Journal: J Neural Transm Suppl Date: 2006

18 in total

Review 1. Restless legs syndrome: pathophysiology, clinical presentation and management.

Authors: Claudia Trenkwalder; Walter Paulus
Journal: Nat Rev Neurol Date: 2010-06 Impact factor: 42.937

2. Sleep Medicine: Restless Legs Syndrome.

Authors: Pradeep C Bollu; Anudeep Yelam; Mahesh M Thakkar
Journal: Mo Med Date: 2018 Jul-Aug

Review 3. Contributions to magnetic susceptibility of brain tissue.

Authors: Jeff H Duyn; John Schenck
Journal: NMR Biomed Date: 2016-05-30 Impact factor: 4.044

4. Iron's role in paediatric restless legs syndrome - a review.

Authors: Cara Dosman; Manisha Witmans; Lonnie Zwaigenbaum
Journal: Paediatr Child Health Date: 2012-04 Impact factor: 2.253

5. Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.

Authors: Pan Chen; Melissa Totten; Ziyan Zhang; Hana Bucinca; Keith Erikson; Abel Santamaría; Aaron B Bowman; Michael Aschner
Journal: Expert Rev Neurother Date: 2019-02-21 Impact factor: 4.618

Review 6. Systems genetics analysis of iron regulation in the brain.

Authors: Leslie C Jellen; John L Beard; Byron C Jones
Journal: Biochimie Date: 2009-04-22 Impact factor: 4.079

7. Restless legs syndrome, pica, and iron status in blood donors.

Authors: Bryan R Spencer; Steven Kleinman; David J Wright; Simone A Glynn; David B Rye; Joseph E Kiss; Alan E Mast; Ritchard G Cable
Journal: Transfusion Date: 2013-06-13 Impact factor: 3.157

Review 8. Dopamine agonists for restless legs syndrome.

Authors: Hanna Scholz; Claudia Trenkwalder; Ralf Kohnen; Dieter Riemann; Levente Kriston; Magdolna Hornyak
Journal: Cochrane Database Syst Rev Date: 2011-03-16

9. Parkinson's disease and sleep/wake disturbances.

Authors: Todd J Swick
Journal: Parkinsons Dis Date: 2012-12-30

Review 10. Levodopa for restless legs syndrome.

Authors: Hanna Scholz; Claudia Trenkwalder; Ralf Kohnen; Dieter Riemann; Levente Kriston; Magdolna Hornyak
Journal: Cochrane Database Syst Rev Date: 2011-02-16