Literature DB >> 18459759

Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.

Richard W Friesen1, Joseph A Mancini.   

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Year:  2008        PMID： 18459759     DOI： 10.1021/jm800197b

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  20 in total

1.  Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.

Authors:  Hui-Hua Chang; Zuohe Song; Lee Wisner; Tina Tripp; Vijay Gokhale; Emmanuelle J Meuillet
Journal:  Invest New Drugs       Date:  2011-09-20       Impact factor: 3.850

2.  Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1.

Authors:  Dong-juan Zhang; Li-hong Chen; Ya-hua Zhang; Guang-rui Yang; Dou Dou; Yuan-sheng Gao; Xiao-yan Zhang; Xiao-mu Kong; Pan Zhao; Dan Pu; Ming-fen Wei; Matthew-D Breyer; You-fei Guan
Journal:  Acta Pharmacol Sin       Date:  2010-09-27       Impact factor: 6.150

3.  Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production.

Authors:  Michel David dos Santos; Guanjie Chen; Maria Camila Almeida; Denis Melo Soares; Glória Emília Petto de Souza; Norberto Peporine Lopes; R Clark Lantz
Journal:  Nat Prod Commun       Date:  2010-05       Impact factor: 0.986

4.  Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis.

Authors:  Adel Hamza; Min Tong; Mohamed Diwan M AbdulHameed; Junjun Liu; Alan C Goren; Hsin-Hsiung Tai; Chang-Guo Zhan
Journal:  J Phys Chem B       Date:  2010-04-29       Impact factor: 2.991

5.  Novel human mPGES-1 inhibitors identified through structure-based virtual screening.

Authors:  Adel Hamza; Xinyun Zhao; Min Tong; Hsin-Hsiung Tai; Chang-Guo Zhan
Journal:  Bioorg Med Chem       Date:  2011-08-25       Impact factor: 3.641

6.  Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.

Authors:  Federico Medda; Earlphia Sells; Hui-Hua Chang; Justin Dietrich; Shashi Chappeta; Breland Smith; Vijay Gokhale; Emmanuelle J Meuillet; Christopher Hulme
Journal:  Bioorg Med Chem Lett       Date:  2012-11-21       Impact factor: 2.823

Review 7.  Rationally designed multitarget agents against inflammation and pain.

Authors:  S H Hwang; A T Wecksler; K Wagner; B D Hammock
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

8.  Selective inhibitors of human mPGES-1 from structure-based computational screening.

Authors:  Ziyuan Zhou; Yaxia Yuan; Shuo Zhou; Kai Ding; Fang Zheng; Chang-Guo Zhan
Journal:  Bioorg Med Chem Lett       Date:  2017-06-29       Impact factor: 2.823

9.  Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.

Authors:  Lihong Chen; Guangrui Yang; Tingting Jiang; Soon Yew Tang; Tao Wang; Qing Wan; Miao Wang; Garret A FitzGerald
Journal:  J Pharmacol Exp Ther       Date:  2019-04-16       Impact factor: 4.030

10.  Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).

Authors:  Birgit Waltenberger; Katja Wiechmann; Julia Bauer; Patrick Markt; Stefan M Noha; Gerhard Wolber; Judith M Rollinger; Oliver Werz; Daniela Schuster; Hermann Stuppner
Journal:  J Med Chem       Date:  2011-04-20       Impact factor: 7.446
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