Literature DB >> 18459062

Impairment of long-term graft function after kidney transplantation by intraoperative vascular complications.

Guido Fechner1, Carolin von Pezold, Stefan Hauser, Thomas Gerhardt, Hans-Ulrich Klehr, Stefan C Müller.   

Abstract

OBJECTIVE: Surgical complications in kidney transplantation often demand reoperation and therefore may severely affect graft survival. Major complications can be divided into ureteral and vascular related. Reoperation for ureteral complications is supposed to worsen graft survival, but vascular complications or anastomosis technique has not been evaluated for this issue. PATIENTS AND METHODS: Between 1994 and 2004 260 patients underwent kidney transplantation. All ureterovesical junctions were performed in extravesical technique with ureteral stenting in 132/260 (50.7%) patients. Arterial end-to-side anastomosis was performed routinely except for 13/260 (5%) with end-to-end anastomosis. Mean follow-up was 43 months (0-121) including serum creatinine and ultrasound inter alia.
RESULTS: Graft failure rate was 8.1% 12 months and 12.7% 60 months postoperatively. Of the patients, 29/260 (11.5%) underwent reoperation within 30 days after transplantation (stenosis or leakage of the ureterovesical junction: n = 8; vascular complications: n = 10; thrombectomy for graft vein thrombosis: n = 1; evacuation of hematoma: n = 6; nephrectomy for complete graft ischemia: n = 4). Reoperation for vascular-related complications significantly enhances the risk of graft failure (P < 0.05, Cox proportional hazard) compared to urological complications. Arterial end-to-end anastomosis was also found to have a negative impact on graft survival. No correlation between routine ureteral stenting and ureteral stenosis or leakage was found.
CONCLUSION: Our data emphasize the importance of vascular complications compared to ureteral ones in kidney transplantation. Resolving 'non-urological' problems successfully, kidney transplantation is a safe procedure in urological hands.

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Year:  2008        PMID: 18459062     DOI: 10.1007/s11255-008-9387-y

Source DB:  PubMed          Journal:  Int Urol Nephrol        ISSN: 0301-1623            Impact factor:   2.370


  12 in total

1.  Long-term graft survival after urological complications of 695 kidney transplantations.

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Review 2.  Transplant renal artery stenosis.

Authors:  Simona Bruno; Giuseppe Remuzzi; Piero Ruggenenti
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Review 3.  2005 immunosuppressive strategies in kidney transplantation: which role for the calcineurin inhibitors?

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Journal:  Transplantation       Date:  2005-08-15       Impact factor: 4.939

Review 4.  Renal transplantation.

Authors:  M Suthanthiran; T B Strom
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5.  Single-center study of technical graft loss in 714 consecutive renal transplants.

Authors:  Michael J Englesbe; Jeffery D Punch; Douglas R Armstrong; Juan D Arenas; Randall S Sung; John C Magee
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6.  Ureteric complications of renal transplantation.

Authors:  S H Kashi; J P Lodge; G R Giles; H C Irving
Journal:  Br J Urol       Date:  1992-08

7.  Graft and patient outcomes among recipients of renal grafts with multiple arteries.

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8.  Consequences of iliac arterial atheroma on renal transplantation.

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Journal:  J Urol       Date:  2006-03       Impact factor: 7.450

9.  Surgically treated early complications after kidney transplantation.

Authors:  R Król; L Cierpka; J Ziaja; J Pawlicki; G Budziński
Journal:  Transplant Proc       Date:  2003-09       Impact factor: 1.066

10.  The outcome of kidney transplants with multiple renal arteries.

Authors:  Cagatay Aydin; Ibrahim Berber; Gulum Altaca; Bulent Yigit; Izzet Titiz
Journal:  BMC Surg       Date:  2004-02-12       Impact factor: 2.102

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  2 in total

1.  Analysis of outcome of end-to-end and end-to-side internal iliac artery anastomosis in renal transplantation: Our initial experience with a case series.

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Journal:  Urol Ann       Date:  2017 Apr-Jun

2.  Vascular and haemorrhagic complications of adult and paediatric live-donor renal transplantation: A single-centre study with a long-term follow-up.

Authors:  Shady A Soliman; Ahmed A Shokeir; Ahmed S El-Hefnawy; Ahmed M Harraz; Mohamed M Kamal; Ahmed B Shehab El-Din; Mohamed A Ghoneim
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  2 in total

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