Literature DB >> 1845904

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.

T Crook1, C Fisher, K H Vousden.   

Abstract

The E7 protein is one of the principle transforming proteins encoded by human papillomavirus type 16 (HPV16), a virus strongly associated with the development of cervical carcinoma. In the present study we show that cotransfection of wild-type human or murine p53 sequences with E7 and ras markedly reduces transformation in baby rat kidney cells, although no effect of p53 is seen on the ability of E7 to transform an established mouse line to anchorage independence. In contrast, expression of mutant p53 strongly potentiates the transforming function of E7 and confers marked growth factor independence to cells cotransformed by E7 and ras. These data suggest that E7 and p53 function in separate yet complementary biochemical pathways.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1845904      PMCID： PMC240547     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  43 in total

1.  Meth A fibrosarcoma cells express two transforming mutant p53 species.

Authors:  D Eliyahu; N Goldfinger; O Pinhasi-Kimhi; G Shaulsky; Y Skurnik; N Arai; V Rotter; M Oren
Journal:  Oncogene       Date:  1988-09       Impact factor: 9.867

2.  Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and IGF-1 genes.

Authors:  X X Gai; M G Rizzo; J Lee; A Ullrich; R Baserga
Journal:  Oncogene Res       Date:  1988

3.  Inhibition of cell growth mediated by plasmids encoding p53 anti-sense.

Authors:  O Shohat; M Greenberg; D Reisman; M Oren; V Rotter
Journal:  Oncogene       Date:  1987       Impact factor: 9.867

4.  The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.

Authors:  K Münger; W C Phelps; V Bubb; P M Howley; R Schlegel
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

5.  SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.

Authors:  J A DeCaprio; J W Ludlow; J Figge; J Y Shew; C M Huang; W H Lee; E Marsilio; E Paucha; D M Livingston
Journal:  Cell       Date:  1988-07-15       Impact factor: 41.582

6.  Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.

Authors:  P Whyte; K J Buchkovich; J M Horowitz; S H Friend; M Raybuck; R A Weinberg; E Harlow
Journal:  Nature       Date:  1988-07-14       Impact factor: 49.962

7.  The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.

Authors:  N Dyson; P M Howley; K Münger; E Harlow
Journal:  Science       Date:  1989-02-17       Impact factor: 47.728

8.  Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

Authors:  T Crook; A Storey; N Almond; K Osborn; L Crawford
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

9.  p53: a frequent target for genetic abnormalities in lung cancer.

Authors:  T Takahashi; M M Nau; I Chiba; M J Birrer; R K Rosenberg; M Vinocour; M Levitt; H Pass; A F Gazdar; J D Minna
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

10.  Comparison of the in vitro transforming activities of human papillomavirus types.

Authors:  A Storey; D Pim; A Murray; K Osborn; L Banks; L Crawford
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598
View more
  7 in total

1.  Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

Authors:  E Shaulian; A Zauberman; D Ginsberg; M Oren
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

2.  Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.

Authors:  M F Kulesz-Martin; B Lisafeld; H Huang; N D Kisiel; L Lee
Journal:  Mol Cell Biol       Date:  1994-03       Impact factor: 4.272

3.  Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

Authors:  S Rowan; R L Ludwig; Y Haupt; S Bates; X Lu; M Oren; K H Vousden
Journal:  EMBO J       Date:  1996-02-15       Impact factor: 11.598

4.  p53 is frequently mutated in Burkitt's lymphoma cell lines.

Authors:  P J Farrell; G J Allan; F Shanahan; K H Vousden; T Crook
Journal:  EMBO J       Date:  1991-10       Impact factor: 11.598

5.  The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

Authors:  J M Slingerland; J R Jenkins; S Benchimol
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598

6.  Mutation of the endogenous p53 gene in cells transformed by HPV-16 E7 and EJ c-ras confers a growth advantage involving an autocrine mechanism.

Authors:  J W Peacock; S Benchimol
Journal:  EMBO J       Date:  1994-03-01       Impact factor: 11.598

7.  p53 mutations in cervical carcinogenesis--low frequency and lack of correlation with human papillomavirus status.

Authors:  R M Busby-Earle; C M Steel; A R Williams; B Cohen; C C Bird
Journal:  Br J Cancer       Date:  1994-04       Impact factor: 7.640
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.