PURPOSE: Our aim was to investigate outpatient antibiotic use and assess the impacts of intervention in five Chinese children's hospitals from 2002 to 2006. METHODS: The Anatomical Therapeutical Chemical Classification/Defined Daily Doses and Drug Utilization 90% methodologies were used. We also analyzed the relationship between antibiotic consumption and resistant rate in one of the hospitals. RESULTS: The overall antibiotic consumption decreased during the intervention period in some hospitals, and the variation in use between hospitals was also reduced. A decrease in penicillins and first-generation cephalosporins, and an increase in third-generation cephalosporins as well as in the combinations of penicillins and beta-lactamase inhibitors were observed. In addition, an increasing resistance to antibiotics was a concern due to antibiotic overconsumption. CONCLUSIONS: The intervention had effects on the overall antibiotic use in outpatients. However, over the span of 5 years, there was a decrease in the use of narrow-spectrum antibiotics and an increase in broad-spectrum antibiotics.
PURPOSE: Our aim was to investigate outpatient antibiotic use and assess the impacts of intervention in five Chinese children's hospitals from 2002 to 2006. METHODS: The Anatomical Therapeutical Chemical Classification/Defined Daily Doses and Drug Utilization 90% methodologies were used. We also analyzed the relationship between antibiotic consumption and resistant rate in one of the hospitals. RESULTS: The overall antibiotic consumption decreased during the intervention period in some hospitals, and the variation in use between hospitals was also reduced. A decrease in penicillins and first-generation cephalosporins, and an increase in third-generation cephalosporins as well as in the combinations of penicillins and beta-lactamase inhibitors were observed. In addition, an increasing resistance to antibiotics was a concern due to antibiotic overconsumption. CONCLUSIONS: The intervention had effects on the overall antibiotic use in outpatients. However, over the span of 5 years, there was a decrease in the use of narrow-spectrum antibiotics and an increase in broad-spectrum antibiotics.
Authors: Christopher J Stille; Susan E Andrade; Susan S Huang; James Nordin; Marsha A Raebel; Alan S Go; K Arnold Chan; Jonathan A Finkelstein Journal: Pediatrics Date: 2004-11 Impact factor: 7.124
Authors: Jonathan A Finkelstein; Christopher Stille; James Nordin; Robert Davis; Marsha A Raebel; Douglas Roblin; Alan S Go; David Smith; Christine C Johnson; Kenneth Kleinman; K Arnold Chan; Richard Platt Journal: Pediatrics Date: 2003-09 Impact factor: 7.124
Authors: Xinping Zhang; Youwen Cui; Chaojie Liu; Keyuan Zuo; Yuqing Tang Journal: Int J Environ Res Public Health Date: 2019-09-12 Impact factor: 3.390