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Literature DB >> 18458135

Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.

Susanne Perkhofer¹, Maria Locher, Manuel Cuenca-Estrella, Reinhard Rüchel, Reinhard Würzner, Manfred P Dierich, Cornelia Lass-Flörl.

Abstract

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18458135 PMCID： PMC2443899 DOI： 10.1128/AAC.00492-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

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Review 4. Zygomycetes in human disease.

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3. Rare mould infections caused by Mucorales, Lomentospora prolificans and Fusarium, in San Diego, CA: the role of antifungal combination therapy.

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Review 5. Fungal infections in transplant and oncology patients.

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6. Activity of posaconazole and other antifungal agents against Mucorales strains identified by sequencing of internal transcribed spacers.

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7. Internal transcribed spacer region sequence heterogeneity in Rhizopus microsporus: implications for molecular diagnosis in clinical microbiology laboratories.

Authors: Patrick C Y Woo; Shui-Yee Leung; Kelvin K W To; Jasper F W Chan; Antonio H Y Ngan; Vincent C C Cheng; Susanna K P Lau; Kwok-Yung Yuen
Journal: J Clin Microbiol Date: 2009-11-11 Impact factor: 5.948

Review 8. Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3).

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9. Outbreak of intestinal infection due to Rhizopus microsporus.

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