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Literature DB >> 18457655

The actin binding protein, fesselin, is a member of the synaptopodin family.

Mechthild M Schroeter¹, Brent Beall, Hans W Heid, Joseph M Chalovich.

Abstract

Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively unfolded proteins, fesselin has multiple binding partners including actin, myosin, calmodulin and alpha-actinin. Fesselin accelerates actin polymerization and bundles actin. These and other observations suggest that fesselin is a component of the cytoskeleton. We have now cloned fesselin and have determined the cDNA derived amino acid sequence. We verified parts of the sequence by Edman analysis and by mass spectroscopy. Our results confirmed fesselin is homologous to human synaptopodin 2 and belongs to the synaptopodin family of proteins.

Entities: Gene Species

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Year: 2008 PMID： 18457655 PMCID： PMC2453309 DOI： 10.1016/j.bbrc.2008.04.134

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

21 in total

Review 1. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains.

Authors: B K Kay; M P Williamson; M Sudol
Journal: FASEB J Date: 2000-02 Impact factor: 5.191

2. Fesselin, a synaptopodin-like protein, stimulates actin nucleation and polymerization.

Authors: B Beall; J M Chalovich
Journal: Biochemistry Date: 2001-11-27 Impact factor: 3.162

3. Fesselin: a novel synaptopodin-like actin binding protein from muscle tissue.

Authors: B D Leinweber; R S Fredricksen; D R Hoffman; J M Chalovich
Journal: J Muscle Res Cell Motil Date: 1999-08 Impact factor: 2.698

Review 4. PDZ domains - common players in the cell signaling.

Authors: Filip Jeleń; Arkadiusz Oleksy; Katarzyna Smietana; Jacek Otlewski
Journal: Acta Biochim Pol Date: 2003 Impact factor: 2.149

5. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

6. Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers.

Authors: F Lin; Y P Yu; J Woods; K Cieply; B Gooding; P Finkelstein; R Dhir; D Krill; M J Becich; G Michalopoulos; S Finkelstein; J H Luo
Journal: Am J Pathol Date: 2001-11 Impact factor: 4.307

7. Ca2+-calmodulin regulates fesselin-induced actin polymerization.

Authors: Mechthild Schroeter; Joseph M Chalovich
Journal: Biochemistry Date: 2004-11-02 Impact factor: 3.162

8. Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome.

Authors: Marta Sanchez-Carbayo; Karin Schwarz; Elizabeth Charytonowicz; Carlos Cordon-Cardo; Peter Mundel
Journal: Oncogene Date: 2003-08-14 Impact factor: 9.867

9. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.

Authors: Thomas Deller; Martin Korte; Sophie Chabanis; Alexander Drakew; Herbert Schwegler; Giulia Good Stefani; Aimee Zuniga; Karin Schwarz; Tobias Bonhoeffer; Rolf Zeller; Michael Frotscher; Peter Mundel
Journal: Proc Natl Acad Sci U S A Date: 2003-08-19 Impact factor: 11.205

10. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.

Authors: A Weins; K Schwarz; C Faul; L Barisoni; W A Linke; P Mundel
Journal: J Cell Biol Date: 2001-10-22 Impact factor: 10.539

5 in total

Review 1. Synaptopodin family of natively unfolded, actin binding proteins: physical properties and potential biological functions.

Authors: Joseph M Chalovich; Mechthild M Schroeter
Journal: Biophys Rev Date: 2010-11-20