| Literature DB >> 18457050 |
O M Panasenko1, T V Vakhrusheva, I I Vlasova, A V Chekanov, Y V Baranov, V I Sergienko.
Abstract
The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro- or bromohydrins and lysophospholipids) and free-radical (paralleled by lipid peroxidation). These reactions modify physicochemical properties of low-density lipoproteins and disorder their lipid-transporting function thus initiating early stages of atherosclerosis development.Entities:
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Year: 2007 PMID： 18457050 DOI： 10.1007/s10517-007-0346-x
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804