Literature DB >> 18457003

Role of statins in cerebral vasospasm.

T Sugawara1, R Ayer, J H Zhang.   

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.

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Year:  2008        PMID： 18457003      PMCID： PMC2743544          DOI： 10.1007/978-3-211-75718-5_59

Source DB:  PubMed          Journal:  Acta Neurochir Suppl        ISSN： 0065-1419


  43 in total

1.  Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

Authors:  Matthew J McGirt; John R Lynch; Augusto Parra; Huaxin Sheng; Robert D Pearlstein; Daniel T Laskowitz; Dale A Pelligrino; David S Warner
Journal:  Stroke       Date:  2002-12       Impact factor: 7.914

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Journal:  Circulation       Date:  2003-04-28       Impact factor: 29.690

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6.  Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.

Authors:  Cecil O Borel; Andy McKee; Augusto Parra; Michael M Haglund; Amy Solan; Vikas Prabhakar; Huaxin Sheng; David S Warner; Laura Niklason
Journal:  Stroke       Date:  2003-02       Impact factor: 7.914

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Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

8.  Simvastatin but not pravastatin inhibits the proliferation of rat aorta myocytes.

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Journal:  Pharmacol Res       Date:  1991-02       Impact factor: 7.658

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Authors:  K Nakazono; N Watanabe; K Matsuno; J Sasaki; T Sato; M Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

10.  Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway.

Authors:  Sebastian Wolfrum; Andreas Dendorfer; Morten Schutt; Britta Weidtmann; Angelika Heep; Klaus Tempel; Harald H Klein; Peter Dominiak; Gert Richardt
Journal:  J Cardiovasc Pharmacol       Date:  2004-09       Impact factor: 3.105
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  6 in total

Review 1.  Statins in the management of patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

Authors:  Andreas H Kramer; Jeffrey J Fletcher
Journal:  Neurocrit Care       Date:  2010-04       Impact factor: 3.210

2.  High-Dose Simvastatin Is Effective in Preventing Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study in Korean Patients.

Authors:  Sung Woong Woo; Jae Hoon Kim; Hee In Kang; Deok Ryeong Kim; Byung Gwan Moon; Joo Seung Kim
Journal:  J Korean Neurosurg Soc       Date:  2015-10-30

3.  Statins in the critically ill.

Authors:  Isabelle De Loecker; Jean-Charles Preiser
Journal:  Ann Intensive Care       Date:  2012-06-18       Impact factor: 6.925

4.  Pleiotropic effects of the HMG-CoA reductase inhibitors.

Authors:  Christos G Mihos; Orlando Santana
Journal:  Int J Gen Med       Date:  2011-04-04

5.  Effects of statins-use for patients with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials.

Authors:  Shao-Hua Su; Wei Xu; Jian Hai; Yi-Fang Wu; Fei Yu
Journal:  Sci Rep       Date:  2014-04-25       Impact factor: 4.379

6.  Effects of clazosentan, cilostazol, and statins on aneurysmal subarachnoid hemorrhage: A protocol for systematic review and meta-analysis.

Authors:  Junfang He; Li Zhang; Yao Yu; Xinyue Luo; Min Wei; Gen Chen; Yanfei Shen
Journal:  Medicine (Baltimore)       Date:  2020-04       Impact factor: 1.889
  6 in total

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