Literature DB >> 18456502

Isolation and antimalarial activity of new morphinan alkaloids on Plasmodium yoelii liver stage.

Maëlle Carraz1, Akino Jossang, Philippe Rasoanaivo, Dominique Mazier, François Frappier.   

Abstract

Decoction of Strychnopsis thouarsii is used in the Malagasy traditional medicine to combat malaria. We have shown that this traditional remedy prevents malaria infection by targeting Plasmodium at its early liver stage. Bioassay-guided fractionation of S. thouarsii stem barks extracts, using a rodent Plasmodium yoelii liver stage parasites inhibition assay, led to isolate the new morphinan alkaloid tazopsine (1) together with sinococuline (2) and two other new related morphinan analogs, 10-epi-tazopsine (3) and 10-epi-tazoside (4). Structures were characterized by 2D NMR, MS, and CD spectral analysis. Compounds 1-3 were found to fully inhibit the rodent P. yoelii liver stage parasites in vitro.

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Year:  2008        PMID： 18456502     DOI： 10.1016/j.bmc.2008.04.033

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.

Authors:  Agam Prasad Singh; Yonghui Zhang; Joo-Hwan No; Roberto Docampo; Victor Nussenzweig; Eric Oldfield
Journal:  Antimicrob Agents Chemother       Date:  2010-05-10       Impact factor: 5.191

2.  Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

Authors:  Sandhya Kortagere; William J Welsh; Joanne M Morrisey; Thomas Daly; Ijeoma Ejigiri; Photini Sinnis; Akhil B Vaidya; Lawrence W Bergman
Journal:  J Chem Inf Model       Date:  2010-05-24       Impact factor: 4.956

3.  FK-3000 isolated from Stephania delavayi Diels. inhibits MDA-MB-231 cell proliferation by decreasing NF-κB phosphorylation and COX-2 expression.

Authors:  Hong De Xu; Soon-Chang Cho; Mi-Ae Bang; Chun-Sik Bae; Yeonshik Choi; Yong-Chun Li; Seung-Kil Lim; Jaegal Shim; Dae-Hun Park
Journal:  Int J Oncol       Date:  2015-03-27       Impact factor: 5.650

4.  Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids.

Authors:  Antoinette Keita; Jean-François Franetich; Maëlle Carraz; Loïse Valentin; Mallaury Bordessoules; Ludivine Baron; Pierre Bigeard; Florian Dupuy; Valentine Geay; Maurel Tefit; Véronique Sarrasin; Sylvie Michel; Catherine Lavazec; Sandrine Houzé; Dominique Mazier; Valérie Soulard; François-Hugues Porée; Romain Duval
Journal:  Pharmaceutics       Date:  2022-02-07       Impact factor: 6.321

Review 5.  Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.

Authors:  Jackson M Muema; Joel L Bargul; Meshack A Obonyo; Sospeter N Njeru; Damaris Matoke-Muhia; James M Mutunga
Journal:  Parasit Vectors       Date:  2022-08-24       Impact factor: 4.047

6.  Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging.

Authors:  Ivo H J Ploemen; Miguel Prudêncio; Bruno G Douradinha; Jai Ramesar; Jannik Fonager; Geert-Jan van Gemert; Adrian J F Luty; Cornelus C Hermsen; Robert W Sauerwein; Fernanda G Baptista; Maria M Mota; Andrew P Waters; Ivo Que; Clemens W G M Lowik; Shahid M Khan; Chris J Janse; Blandine M D Franke-Fayard
Journal:  PLoS One       Date:  2009-11-18       Impact factor: 3.240
  6 in total

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