Literature DB >> 18455982

Tenets of PTEN tumor suppression.

Leonardo Salmena1, Arkaitz Carracedo, Pier Paolo Pandolfi.   

Abstract

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and regulation, and speculates about how manipulation of PTEN function could be used for cancer therapy.

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Year:  2008        PMID： 18455982     DOI： 10.1016/j.cell.2008.04.013

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  471 in total

1.  PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.

Authors:  Y Qi; J Liu; S Saadat; X Tian; Y Han; G-H Fong; P P Pandolfi; L Y Lee; S Li
Journal:  Cell Death Differ       Date:  2014-11-14       Impact factor: 15.828

2.  PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

Authors:  Brian McEllin; Cristel V Camacho; Bipasha Mukherjee; Brandon Hahm; Nozomi Tomimatsu; Robert M Bachoo; Sandeep Burma
Journal:  Cancer Res       Date:  2010-06-08       Impact factor: 12.701

Review 3.  Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development.

Authors:  W-L Yang; X Zhang; H-K Lin
Journal:  Oncogene       Date:  2010-06-07       Impact factor: 9.867

4.  MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2.

Authors:  Jia Yu; Han Peng; Qing Ruan; Anees Fatima; Spiro Getsios; Robert M Lavker
Journal:  FASEB J       Date:  2010-06-07       Impact factor: 5.191

5.  Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.

Authors:  Shiuan Wey; Biquan Luo; Chun-Chih Tseng; Min Ni; Hui Zhou; Yong Fu; Deepa Bhojwani; William L Carroll; Amy S Lee
Journal:  Blood       Date:  2011-09-21       Impact factor: 22.113

Review 6.  Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation.

Authors:  G V Baracho; A V Miletic; S A Omori; M H Cato; R C Rickert
Journal:  Curr Opin Immunol       Date:  2011-02-01       Impact factor: 7.486

7.  Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

Authors:  Meng M Rowland; Heidi E Bostic; Denghuang Gong; Anna E Speers; Nathan Lucas; Wonhwa Cho; Benjamin F Cravatt; Michael D Best
Journal:  Biochemistry       Date:  2011-11-30       Impact factor: 3.162

Review 8.  Epigenetic plasticity and the hallmarks of cancer.

Authors:  William A Flavahan; Elizabeth Gaskell; Bradley E Bernstein
Journal:  Science       Date:  2017-07-21       Impact factor: 47.728

Review 9.  The microRNA networks of TGFβ signaling in cancer.

Authors:  V P Sivadas; S Kannan
Journal:  Tumour Biol       Date:  2013-12-10

10.  Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

Authors:  Caterina Nardella; Arkaitz Carracedo; Andrea Alimonti; Robin M Hobbs; John G Clohessy; Zhenbang Chen; Ainara Egia; Alessandro Fornari; Michelangelo Fiorentino; Massimo Loda; Sara C Kozma; George Thomas; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Journal:  Sci Signal       Date:  2009-01-27       Impact factor: 8.192
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