AIMS: Postmortem series have reported that subjects with diabetes mellitus have coronary plaques with larger necrotic cores and increased macrophage infiltration. Optical coherence tomography (OCT) is a high-resolution imaging modality that allows in vivo characterization of atherosclerotic plaques. Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects. METHODS: Sixty-three patients undergoing cardiac catheterization were enrolled. OCT imaging was performed in culprit coronary arteries. Assessment of plaque lipid content, fibrous cap thickness and frequency of thin-cap fibroatheroma were made independently. Macrophage density was determined from the optical signal within fibrous cap. RESULTS: Eighty-two plaques in total were imaged (19 diabetic vs. 63 non-diabetic). There were no significant differences in frequency of lipid-rich plaques (68% vs. 71%; P=0.78), thin-cap fibroatheroma (29% vs. 36%; P=0.76) or minimum fibrous cap thickness (66.6microm vs. 62.9microm; P=0.87) between diabetic and non-diabetic patients. Fibrous cap macrophage density was higher in lipid-rich plaques (P=0.01) but showed no difference between diabetic and non-diabetic patients (5.94% vs. 5.94%; P=0.37). CONCLUSIONS: There were no significant differences in culprit vessel plaque characteristics between diabetic and non-diabetic patients presenting with coronary artery disease. This represents the first study to characterize coronary plaques in diabetic patients using OCT.
AIMS: Postmortem series have reported that subjects with diabetes mellitus have coronary plaques with larger necrotic cores and increased macrophage infiltration. Optical coherence tomography (OCT) is a high-resolution imaging modality that allows in vivo characterization of atherosclerotic plaques. Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects. METHODS: Sixty-three patients undergoing cardiac catheterization were enrolled. OCT imaging was performed in culprit coronary arteries. Assessment of plaque lipid content, fibrous cap thickness and frequency of thin-cap fibroatheroma were made independently. Macrophage density was determined from the optical signal within fibrous cap. RESULTS: Eighty-two plaques in total were imaged (19 diabetic vs. 63 non-diabetic). There were no significant differences in frequency of lipid-rich plaques (68% vs. 71%; P=0.78), thin-cap fibroatheroma (29% vs. 36%; P=0.76) or minimum fibrous cap thickness (66.6microm vs. 62.9microm; P=0.87) between diabetic and non-diabeticpatients. Fibrous cap macrophage density was higher in lipid-rich plaques (P=0.01) but showed no difference between diabetic and non-diabeticpatients (5.94% vs. 5.94%; P=0.37). CONCLUSIONS: There were no significant differences in culprit vessel plaque characteristics between diabetic and non-diabeticpatients presenting with coronary artery disease. This represents the first study to characterize coronary plaques in diabeticpatients using OCT.
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Authors: Jennifer E Phipps; Deborah Vela; Taylor Hoyt; David L Halaney; J Jacob Mancuso; L Maximilian Buja; Reto Asmis; Thomas E Milner; Marc D Feldman Journal: JACC Cardiovasc Imaging Date: 2014-11-05
Authors: Tomoyo Sugiyama; Erika Yamamoto; Krzysztof Bryniarski; Lei Xing; Francesco Fracassi; Hang Lee; Ik-Kyung Jang Journal: J Am Heart Assoc Date: 2018-07-13 Impact factor: 5.501