OBJECTIVE: To verify whether the antral follicle count (AFC) could predict ovarian response, oocyte/embryo quality, and IVF outcome. DESIGN: Prospective study. SETTING: Instituto Universitario-Instituto Valenciano de Infertilidad, Valencia, Spain. PATIENT(S): One thousand seventy-four donors and 975 oocyte recipient cycles. INTERVENTION(S): Controlled ovarian hyperstimulation (COH), endometrial preparation, IVF/intracytoplasmic sperm injection, ET. MAIN OUTCOME MEASURE(S): COH and oocyte/embryo quality parameters and IVF outcome. RESULT(S): We observed lower E(2) levels and fewer mature retrieved oocyte numbers among donors who showed an AFC that was <10. These donors also showed significantly higher cancellation and no-donation rates; poor and/or insufficient response was the principal cause (82%). However, there were no differences among the groups regarding embryo development parameters and IVF outcome. CONCLUSION(S): AFC is a noninvasive and simple tool that can improve the oocyte donor's selection of an egg donation program. This study suggests that AFC is a good predictor of ovarian response but cannot be used to predict oocyte/embryo quality or IVF outcome.
OBJECTIVE: To verify whether the antral follicle count (AFC) could predict ovarian response, oocyte/embryo quality, and IVF outcome. DESIGN: Prospective study. SETTING: Instituto Universitario-Instituto Valenciano de Infertilidad, Valencia, Spain. PATIENT(S): One thousand seventy-four donors and 975 oocyte recipient cycles. INTERVENTION(S): Controlled ovarian hyperstimulation (COH), endometrial preparation, IVF/intracytoplasmic sperm injection, ET. MAIN OUTCOME MEASURE(S): COH and oocyte/embryo quality parameters and IVF outcome. RESULT(S): We observed lower E(2) levels and fewer mature retrieved oocyte numbers among donors who showed an AFC that was <10. These donors also showed significantly higher cancellation and no-donation rates; poor and/or insufficient response was the principal cause (82%). However, there were no differences among the groups regarding embryo development parameters and IVF outcome. CONCLUSION(S): AFC is a noninvasive and simple tool that can improve the oocyte donor's selection of an egg donation program. This study suggests that AFC is a good predictor of ovarian response but cannot be used to predict oocyte/embryo quality or IVF outcome.
Authors: Jessica L Chan; Lauren N C Johnson; Brenda L Efymow; Mary D Sammel; Clarisa R Gracia Journal: J Assist Reprod Genet Date: 2015-09-23 Impact factor: 3.412
Authors: Miguel A Checa; Mario Brassesco; Margalida Sastre; Manuel Gómez; Julio Herrero; Laura Marque; Arturo Brassesco; Juan José Espinós Journal: Int J Womens Health Date: 2015-02-12