Literature DB >> 18453860

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection.

Lishomwa C Ndhlovu1, Joan M Chapman, Aashish R Jha, Jennifer E Snyder-Cappione, Moraima Pagán, Fabio E Leal, Brigid S Boland, Philip J Norris, Michael G Rosenberg, Douglas F Nixon.   

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

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Year:  2008        PMID： 18453860      PMCID： PMC2850608          DOI： 10.1097/QAD.0b013e3282ff884e

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  15 in total

Review 1.  IL-17 family cytokines and the expanding diversity of effector T cell lineages.

Authors:  Casey T Weaver; Robin D Hatton; Paul R Mangan; Laurie E Harrington
Journal:  Annu Rev Immunol       Date:  2007       Impact factor: 28.527

2.  IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

Authors:  Shabaana A Khader; Guy K Bell; John E Pearl; Jeffrey J Fountain; Javier Rangel-Moreno; Garth E Cilley; Fang Shen; Sheri M Eaton; Sarah L Gaffen; Susan L Swain; Richard M Locksley; Laura Haynes; Troy D Randall; Andrea M Cooper
Journal:  Nat Immunol       Date:  2007-03-11       Impact factor: 25.606

3.  Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.

Authors:  J Kennedy; D L Rossi; S M Zurawski; F Vega; R A Kastelein; J L Wagner; C H Hannum; A Zlotnik
Journal:  J Interferon Cytokine Res       Date:  1996-08       Impact factor: 2.607

4.  Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice.

Authors:  Weitao Huang; Li Na; Paul L Fidel; Paul Schwarzenberger
Journal:  J Infect Dis       Date:  2004-06-22       Impact factor: 5.226

5.  Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.

Authors:  Eva V Acosta-Rodriguez; Laura Rivino; Jens Geginat; David Jarrossay; Marco Gattorno; Antonio Lanzavecchia; Federica Sallusto; Giorgio Napolitani
Journal:  Nat Immunol       Date:  2007-05-07       Impact factor: 25.606

6.  Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.

Authors:  Wassim M Ballan; Bien-Aimee N Vu; Brian R Long; Christopher P Loo; Jakob Michaëlsson; Jason D Barbour; Lewis L Lanier; Andrew A Wiznia; Jacobo Abadi; Glenn J Fennelly; Michael G Rosenberg; Douglas F Nixon
Journal:  J Immunol       Date:  2007-09-01       Impact factor: 5.422

7.  Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection.

Authors:  Wirach Maek-A-Nantawat; Supranee Buranapraditkun; Jettanong Klaewsongkram; Kiat Ruxrungtham; Kiat Ruxrungthum
Journal:  Viral Immunol       Date:  2007       Impact factor: 2.257

8.  Human IL-17: a novel cytokine derived from T cells.

Authors:  Z Yao; S L Painter; W C Fanslow; D Ulrich; B M Macduff; M K Spriggs; R J Armitage
Journal:  J Immunol       Date:  1995-12-15       Impact factor: 5.422

9.  Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.

Authors:  Salomé LeibundGut-Landmann; Olaf Gross; Matthew J Robinson; Fabiola Osorio; Emma C Slack; S Vicky Tsoni; Edina Schweighoffer; Victor Tybulewicz; Gordon D Brown; Jürgen Ruland; Caetano Reis e Sousa
Journal:  Nat Immunol       Date:  2007-04-22       Impact factor: 25.606

10.  Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.

Authors:  Jens Lohr; Birgit Knoechel; Jing Jing Wang; Alejandro V Villarino; Abul K Abbas
Journal:  J Exp Med       Date:  2006-11-27       Impact factor: 14.307
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  39 in total

Review 1.  Th17 cell dynamics in HIV infection.

Authors:  Nichole R Klatt; Jason M Brenchley
Journal:  Curr Opin HIV AIDS       Date:  2010-03       Impact factor: 4.283

2.  Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory.

Authors:  Thorsten Demberg; Amelia C Ettinger; Stanley Aladi; Katherine McKinnon; Thea Kuddo; David Venzon; L Jean Patterson; Terry M Phillips; Marjorie Robert-Guroff
Journal:  Vaccine       Date:  2011-06-25       Impact factor: 3.641

3.  SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.

Authors:  Neelam Dhiman; Iana H Haralambieva; Richard B Kennedy; Robert A Vierkant; Megan M O'Byrne; Inna G Ovsyannikova; Robert M Jacobson; Gregory A Poland
Journal:  Immunogenetics       Date:  2010-03-10       Impact factor: 2.846

4.  A randomized case-control study of dynamic changes in peripheral blood Th17/Treg cell balance and interleukin-17 levels in highly active antiretroviral-treated HIV type 1/AIDS patients.

Authors:  Yan He; Jing Li; Yuhuang Zheng; Yan Luo; Huaying Zhou; Yunhai Yao; Xia Chen; Zi Chen; Mei He
Journal:  AIDS Res Hum Retroviruses       Date:  2011-08-30       Impact factor: 2.205

5.  Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.

Authors:  Aimee El Hed; Alka Khaitan; Lina Kozhaya; Nicolas Manel; Demetre Daskalakis; William Borkowsky; Fred Valentine; Dan R Littman; Derya Unutmaz
Journal:  J Infect Dis       Date:  2010-03-15       Impact factor: 5.226

Review 6.  Th17 cells and HIV infection.

Authors:  Aimee Elhed; Derya Unutmaz
Journal:  Curr Opin HIV AIDS       Date:  2010-03       Impact factor: 4.283

7.  Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.

Authors:  F J Ibarrondo; S B Wilson; L E Hultin; R Shih; M A Hausner; P M Hultin; P A Anton; B D Jamieson; O O Yang
Journal:  Mucosal Immunol       Date:  2012-11-14       Impact factor: 7.313

8.  Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection.

Authors:  Georgina Thorborn; Laura Pomeroy; Heidi Isohanni; Melissa Perry; Barry Peters; Annapurna Vyakarnam
Journal:  PLoS One       Date:  2010-02-17       Impact factor: 3.240

Review 9.  Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?

Authors:  A Boasso; G M Shearer; C Chougnet
Journal:  J Intern Med       Date:  2009-01       Impact factor: 8.989

10.  Anti-retroviral therapy fails to restore the severe Th-17: Tc-17 imbalance observed in peripheral blood during simian immunodeficiency virus infection.

Authors:  M Kader; S Bixler; M Piatak; J Lifson; J J Mattapallil
Journal:  J Med Primatol       Date:  2009-10       Impact factor: 0.667
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