| Literature DB >> 1845366 |
M N Gould1, J D Haag, W S Kennan, M A Tanner, C E Elson.
Abstract
Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.Entities:
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Year: 1991 PMID： 1845366 DOI： 10.1093/ajcn/53.4.1068S
Source DB: PubMed Journal: Am J Clin Nutr ISSN： 0002-9165 Impact factor: 7.045