Dyslipidemia and glucose dysregulation in overweight and obese patients.

Inactivity and a sedentary lifestyle contribute to overweight, obesity, and cardiometabolic risk. Overweight and obesity can lead to metabolic abnormalities, insulin resistance, type 2 diabetes mellitus (DM), lipid disorders, and cardiovascular disease. Diet and exercise can effectively reverse overweight and obesity and their related comorbidities. Modest weight loss (5%-10%) and modest physical activity (30 minutes a day) are first-line recommendations for the prevention of type 2 DM. Clinical trials have demonstrated that insulin sensitivity can be improved and type 2 DM can be prevented through lifestyle modification and pharmacologic therapy, including antiobesity drugs, antidiabetic drugs, statins, and antihypertensive drugs. The endocannabinoid system plays an important role in regulating metabolism through its effects on food intake at the level of the hypothalamus and on body composition through peripheral effects on adipose tissue.