OBJECTIVE: To examine relationships between exposure to trauma, bipolar spectrum disorder (BD) and posttraumatic stress disorder (PTSD) in a sample of primary care patients. METHODS: A systematic sample (n = 977) of adult primary care patients from an urban general medicine practice were interviewed with measures including the Mood Disorders Questionnaire, the PTSD Checklist-Civilian Version, and the Medical Outcomes Study 12-Item Short Form Health Survey. RESULTS: Compared with patients who screened negative for BD (n = 881), those who screened positive (n = 96) were 2.6 times [95% confidence interval (CI): 1.6-4.2] as likely to report physical or sexual assault, and 2.9 times (95% CI: 1.6-5.1) as likely to screen positive for current PTSD. Among those screening positive for BD, comorbid PTSD was associated with significantly worse social functioning. These results controlled for selected background characteristics, current major depressive episode, and current alcohol/drug use disorder. CONCLUSION: In an urban general medicine setting, trauma exposure was related to BD, and the frequency of PTSD among patients with BD appears to be common and clinically significant. These results suggest an unmet need for mental health care in this specific population and are especially important in view of available treatments for BD and PTSD.
OBJECTIVE: To examine relationships between exposure to trauma, bipolar spectrum disorder (BD) and posttraumatic stress disorder (PTSD) in a sample of primary care patients. METHODS: A systematic sample (n = 977) of adult primary care patients from an urban general medicine practice were interviewed with measures including the Mood Disorders Questionnaire, the PTSD Checklist-Civilian Version, and the Medical Outcomes Study 12-Item Short Form Health Survey. RESULTS: Compared with patients who screened negative for BD (n = 881), those who screened positive (n = 96) were 2.6 times [95% confidence interval (CI): 1.6-4.2] as likely to report physical or sexual assault, and 2.9 times (95% CI: 1.6-5.1) as likely to screen positive for current PTSD. Among those screening positive for BD, comorbid PTSD was associated with significantly worse social functioning. These results controlled for selected background characteristics, current major depressive episode, and current alcohol/drug use disorder. CONCLUSION: In an urban general medicine setting, trauma exposure was related to BD, and the frequency of PTSD among patients with BD appears to be common and clinically significant. These results suggest an unmet need for mental health care in this specific population and are especially important in view of available treatments for BD and PTSD.
Authors: R M Hirschfeld; J B Williams; R L Spitzer; J R Calabrese; L Flynn; P E Keck; L Lewis; S L McElroy; R M Post; D J Rapport; J M Russell; G S Sachs; J Zajecka Journal: Am J Psychiatry Date: 2000-11 Impact factor: 18.112
Authors: Gabriele S Leverich; Susan L McElroy; Trisha Suppes; Paul E Keck; Kirk D Denicoff; Willem A Nolen; Lori L Altshuler; A John Rush; Ralph Kupka; Mark A Frye; Karen A Autio; Robert M Post Journal: Biol Psychiatry Date: 2002-02-15 Impact factor: 13.382
Authors: Dean F MacKinnon; Peter P Zandi; Jennifer Cooper; James B Potash; Sylvia G Simpson; Elliot Gershon; John Nurnberger; Theodore Reich; J Raymond DePaulo Journal: Am J Psychiatry Date: 2002-01 Impact factor: 18.112