| Literature DB >> 18452095 |
Xavier Leleu1, Anne-Sophie Moreau, Edie Weller, Aldo M Roccaro, ValéRie Coiteux, Robert Manning, Marybeth Nelson, Renee Leduc, Daniela Robu, Sophie Dupire, Evdoxia Hatjiharissi, Nicholas Burwick, Stéphane Darre, Bernadette Hennache, Steven P Treon, Thierry Facon, Morie A Gertz, Irene M Ghobrial.
Abstract
The serum IgM level has been utilised as a marker of tumor progression and to assess response to therapy in patients with Waldenstrom macroglobulinemia (WM). However, there are many limitations to the IgM protein level. The objective of this study was to evaluate the association of known tumor burden markers and prognostic factors with serum free light chain (sFLC) in 98 patients with WM. We demonstrated that sFLC measurement accurately differentiated IgM-MGUS compared with WM reflecting a measurement of tumor burden. In univariate and multivariate analysis, median sFLC at the cut-off at 60 mg/L was higher for WM patients with low hemoglobin and high beta2M, when we applied the WM-IPSS cut-offs, but showed no association with IgM level. This study demonstrates that sFLC is a new marker in WM disease. Further analysis is required to prospectively study the role of sFLC in monitoring response to therapy and as a prognostic marker in WM patients.Entities:
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Year: 2008 PMID： 18452095 DOI： 10.1080/10428190802074619
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022