| Literature DB >> 18452053 |
Alexander N Shikov1, Olga N Pozharitskaya, Valery G Makarov, Marina N Makarova.
Abstract
The anti-inflammatory effect of the oil extract of seeds of Pinus sibirica Du Tour was evaluated and compared with phenylbutazone. Oral administration of this extract at a dose of 300 mg/kg showed anti-inflammatory activity in the carrageenin-induced edema test in rats. In addition, P. sibirica oil extract showed analgesic properties in the hot-plate test and antipyretic properties in adjuvant-induced local hyperthermia, both in rats. In conclusion, these results provide evidence for the potential usefulness of P. sibirica oil extract, a defined mixture of long-chain polyunsaturated fatty acids, sterols, tocopherols and polyphenols, in inflammatory disorders.Entities:
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Year: 2008 PMID： 18452053 DOI： 10.1007/s11418-008-0254-z
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343