Literature DB >> 18451569

New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L.

Ji-Ean Lee1, Yukio Hitotsuyanagi, Haruhiko Fukaya, Kazuyuki Kondo, Koichi Takeya.   

Abstract

Two new bicyclic hexapeptides, RA-XXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 microg/ml, respectively.

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Year:  2008        PMID： 18451569     DOI： 10.1248/cpb.56.730

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  5 in total

1.  Rubiarbonone C inhibits platelet-derived growth factor-induced proliferation and migration of vascular smooth muscle cells through the focal adhesion kinase, MAPK and STAT3 Tyr705 signalling pathways.

Authors:  Hyun-Soo Park; Khong Trong Quan; Joo-Hui Han; Sang-Hyuk Jung; Do-Hyung Lee; Eunji Jo; Tae-Wan Lim; Kyung-Sun Heo; MinKyun Na; Chang-Seon Myung
Journal:  Br J Pharmacol       Date:  2017-09-22       Impact factor: 8.739

2.  Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N9-Methyl Group in the Conformation and Bioactivity.

Authors:  Zhe Wang; Si-Meng Zhao; Li-Mei Zhao; Xiao-Qiang Chen; Guang-Zhi Zeng; Ning-Hua Tan
Journal:  PLoS One       Date:  2015-12-22       Impact factor: 3.240

Review 3.  A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications.

Authors:  Min Wen; Qi Chen; Wang Chen; Jing Yang; Xiaogang Zhou; Chunxiang Zhang; Anguo Wu; Jia Lai; Jianping Chen; Qibing Mei; Shuo Yang; Cai Lan; Jianming Wu; Feihong Huang; Long Wang
Journal:  Front Pharmacol       Date:  2022-09-09       Impact factor: 5.988

4.  Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia.

Authors:  Kuo Xu; Penglong Wang; Bin Yuan; Yatao Cheng; Qiang Li; Haimin Lei
Journal:  Chem Cent J       Date:  2013-05-04       Impact factor: 4.215

Review 5.  Design and synthesis of analogues of RA-VII-an antitumor bicyclic hexapeptide from Rubiae radix.

Authors:  Yukio Hitotsuyanagi
Journal:  J Nat Med       Date:  2021-07-10       Impact factor: 2.343
  5 in total

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