Literature DB >> 18451567

Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens.

Daniara Cristina Fernandes1, Luis Octávio Regasini, José Carlos Rebuglio Vellosa, Patrícia Mendonça Pauletti, Ian Castro-Gamboa, Vanderlan Silva Bolzani, Olga Maria Mascarenhas Oliveira, Dulce Helena Siqueira Silva.   

Abstract

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18451567     DOI： 10.1248/cpb.56.723

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

1.  Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line.

Authors:  Roberta Aparecida Duarte; Elaine Rodrigues Mello; Camila Araki; Vanderlan da Silva Bolzani; Dulce Helena Siqueira e Silva; Luis Octavio Regasini; Tarsia Giabardo Alves Silva; Mauro César Cafundó de Morais; Valdecir Farias Ximenes; Christiane Pienna Soares
Journal:  Tumour Biol       Date:  2010-08-11

2.  Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death.

Authors:  Yasuhiro Tajima; Hayato Murase; Kazuhiro Satake; Yuji Mitani; Luis Octavio Regasini; Vanderlan da Silva Bolzani; Thomas Efferth; Hiroshi Nakagawa
Journal:  Cytotechnology       Date:  2013-07-27       Impact factor: 2.058

3.  Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors.

Authors:  Caroline Sprengel Lima; Melina Mottin; Leticia Ribeiro de Assis; Nathalya Cristina de Moraes Roso Mesquita; Bruna Katiele de Paula Sousa; Lais Durco Coimbra; Karina Bispo-Dos- Santos; Kimberley M Zorn; Rafael V C Guido; Sean Ekins; Rafael Elias Marques; José Luiz Proença-Modena; Glaucius Oliva; Carolina Horta Andrade; Luis Octavio Regasini
Journal:  Bioorg Chem       Date:  2021-02-11       Impact factor: 5.275

4.  Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry.

Authors:  Jacqueline Farinha Shimizu; Caroline Sprengel Lima; Carina Machado Pereira; Cintia Bittar; Mariana Nogueira Batista; Ana Carolina Nazaré; Carlos Roberto Polaquini; Carsten Zothner; Mark Harris; Paula Rahal; Luis Octávio Regasini; Ana Carolina Gomes Jardim
Journal:  Sci Rep       Date:  2017-11-23       Impact factor: 4.379

5.  Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil).

Authors:  Pollyanna Francielli de Oliveira; Suzana Amorim Mendes; Nathália Oliveira Acésio; Luis Claudio Kellner Filho; Leticia Pereira Pimenta; Kátia Aparecida Siqueira; Marcos Antônio Soares; Ana Helena Januário; Denise Crispim Tavares
Journal:  Evid Based Complement Alternat Med       Date:  2018-09-19       Impact factor: 2.629

6.  Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages.

Authors:  Yushiro Fuji; Ayumi Uchida; Katsunori Fukahori; Makoto Chino; Takashi Ohtsuki; Hiroshi Matsufuji
Journal:  PLoS One       Date:  2018-03-27       Impact factor: 3.240

7.  Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae).

Authors:  Aline Coqueiro; Luis Octávio Regasini; Scheila Cristina Gutkoski Skrzek; Marcos Marçal Ferreira Queiroz; Dulce Helena Siqueira Silva; Vanderlan da Silva Bolzani
Journal:  Molecules       Date:  2013-02-19       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.