BACKGROUND AND PURPOSE: Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)-defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS: Seventy-one patients with an asymptomatic carotid stenosis of > or = 40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS: No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS: Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.
BACKGROUND AND PURPOSE:Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)-defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques. METHODS: Seventy-one patients with an asymptomatic carotid stenosis of > or = 40% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods. RESULTS: No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found. CONCLUSIONS:Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.
Authors: C Kaneko; N Nitta; K Tsuchiya; S Watanabe; A Nitta-Seko; S Ohta; H Otani; A Sonoda; K Murata; M Shiomi Journal: Br J Radiol Date: 2015-06-17 Impact factor: 3.039
Authors: A Millon; S D Dickson; A Klink; D Izquierdo-Garcia; J Bini; E Lancelot; S Ballet; P Robert; J Mateo de Castro; C Corot; Z A Fayad Journal: Atherosclerosis Date: 2013-03-26 Impact factor: 5.162