BACKGROUND: Coronary artery calcification (CAC) is prevalent in patients with chronic kidney disease (CKD). Data on the reliability and validity of high-resolution computerized tomography (HRCT) in patients with CKD is lacking. The purpose of this study was to evaluate the inter- and intra-reviewer agreement and inter-scan reproducibility of CACS measurement with HRCT in a cohort of patients with CKD prior to dialysis, and to compare the change in CACS at 30 minutes to the change in CACS over 1 year. METHODS: Thirty-three patients with CKD not yet on dialysis underwent an HRCT scan at baseline and 1 year to assess for CAC and CAC progression. Two radiologists independently reviewed films and each radiologist re-reviewed a randomly selected subset of films they had previously viewed, to assess for inter-reviewer and intra-reviewer reliability, respectively. Patients underwent a repeat scan within 30 min of the first baseline scan to assess for inter-scan reproducibility. RESULTS: At baseline, eight patients (24%) had no CAC. Of the 25 patients (76%) with CAC, 10 (40%) had severe calcification. Intra-reviewer agreement was 83%. Inter-reviewer agreement ranged between 77 and 94%. Six (27%) of the patients with >30 baseline CACS had >15% change in CACS following repositioning. Four of these patients had an increase in CACS with position change [18% (95% CI: 5-40%)]. Of the 21 patients who underwent a follow-up scan at 1 year, 7 (33%) demonstrated CACS progression. CONCLUSIONS: There is significant imprecision in HRCT-derived CACS in CKD patients. This suggests a need for standardization of methods of CACS measurement with HRCT.
BACKGROUND:Coronary artery calcification (CAC) is prevalent in patients with chronic kidney disease (CKD). Data on the reliability and validity of high-resolution computerized tomography (HRCT) in patients with CKD is lacking. The purpose of this study was to evaluate the inter- and intra-reviewer agreement and inter-scan reproducibility of CACS measurement with HRCT in a cohort of patients with CKD prior to dialysis, and to compare the change in CACS at 30 minutes to the change in CACS over 1 year. METHODS: Thirty-three patients with CKD not yet on dialysis underwent an HRCT scan at baseline and 1 year to assess for CAC and CAC progression. Two radiologists independently reviewed films and each radiologist re-reviewed a randomly selected subset of films they had previously viewed, to assess for inter-reviewer and intra-reviewer reliability, respectively. Patients underwent a repeat scan within 30 min of the first baseline scan to assess for inter-scan reproducibility. RESULTS: At baseline, eight patients (24%) had no CAC. Of the 25 patients (76%) with CAC, 10 (40%) had severe calcification. Intra-reviewer agreement was 83%. Inter-reviewer agreement ranged between 77 and 94%. Six (27%) of the patients with >30 baseline CACS had >15% change in CACS following repositioning. Four of these patients had an increase in CACS with position change [18% (95% CI: 5-40%)]. Of the 21 patients who underwent a follow-up scan at 1 year, 7 (33%) demonstrated CACS progression. CONCLUSIONS: There is significant imprecision in HRCT-derived CACS in CKDpatients. This suggests a need for standardization of methods of CACS measurement with HRCT.
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Authors: Francesca Solagna; Caterina Tezze; Maja T Lindenmeyer; Shun Lu; Guochao Wu; Shuya Liu; Yu Zhao; Robert Mitchell; Charlotte Meyer; Saleh Omairi; Temel Kilic; Andrea Paolini; Olli Ritvos; Arja Pasternack; Antonios Matsakas; Dominik Kylies; Julian Schulze Zur Wiesch; Jan-Eric Turner; Nicola Wanner; Viji Nair; Felix Eichinger; Rajasree Menon; Ina V Martin; Barbara M Klinkhammer; Elion Hoxha; Clemens D Cohen; Pierre-Louis Tharaux; Peter Boor; Tammo Ostendorf; Matthias Kretzler; Marco Sandri; Oliver Kretz; Victor G Puelles; Ketan Patel; Tobias B Huber Journal: J Clin Invest Date: 2021-06-01 Impact factor: 14.808