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Literature DB >> 1845037

Frontal lobe dysfunction following infarction of the left-sided medial thalamus.

T A Sandson¹, K R Daffner, P A Carvalho, M M Mesulam.

Abstract

We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.

Entities: Disease Species

Mesh：

Year: 1991 PMID： 1845037 DOI： 10.1001/archneur.1991.00530240106031

Source DB: PubMed Journal: Arch Neurol ISSN： 0003-9942

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Cited

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Frontal lobe dysfunction following infarction of the left-sided medial thalamus.

1. Social cognition in Alzheimer's disease: a separate construct contributing to dependence.

2. Disorders of higher mental function due to single infarctions in the thalamus and in the area of the thalamofrontal tracts.

3. Focal brain atrophy in gastric bypass patients with cognitive complaints.

Review 4. Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease.

5. Persistent pure verbal amnesia and transient aphasia after left thalamic infarction.

6. Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy.

7. Neuropsychological correlates of a right unilateral lacunar thalamic infarction.

8. Working memory in 8 Kleine-Levin syndrome patients: an fMRI study.

Review 9. Frontal-subcortical circuitry and behavior.

10. The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition.