OBJECTIVE: Differences in overall survival (OS) and disease-free survival (DFS) between patients with invasive ductal (IDC) and invasive lobular breast cancer (ILC) are controversial. STUDY DESIGN: The study population was selected from a database of 5,689 female patients with invasive breast cancer. In order to focus on the impact of tumour histology, all primary metastatic patients and patients with adjuvant chemotherapy or anti-hormonal treatment were excluded. Only patients with pure invasive lobular and invasive ductal histology were included. RESULTS: Multivariate survival analyses of 2,058 eligible patients confirmed tumour histology as an independent prognostic factor for OS in invasive breast cancer (p = 0.046) but not for DFS (p = 0.599). Kaplan-Meier survival analysis of OS between IDC and ILC patients showed a statistically significantly better OS for patients with ILC (p = 0.0302). DFS was not statistically different (p = 0.6659) between IDC and ILC. Univariate survival analyses of tumour size, tumour grading and nodal status in our study population were highly statistically significant for OS and DFS (p < 0.0000). CONCLUSION: Patients in our study population with ILC have significantly better OS than patients with IDC. Differences in DFS are not statistically significant.
OBJECTIVE: Differences in overall survival (OS) and disease-free survival (DFS) between patients with invasive ductal (IDC) and invasive lobular breast cancer (ILC) are controversial. STUDY DESIGN: The study population was selected from a database of 5,689 female patients with invasive breast cancer. In order to focus on the impact of tumour histology, all primary metastatic patients and patients with adjuvant chemotherapy or anti-hormonal treatment were excluded. Only patients with pure invasive lobular and invasive ductal histology were included. RESULTS: Multivariate survival analyses of 2,058 eligible patients confirmed tumour histology as an independent prognostic factor for OS in invasive breast cancer (p = 0.046) but not for DFS (p = 0.599). Kaplan-Meier survival analysis of OS between IDC and ILC patients showed a statistically significantly better OS for patients with ILC (p = 0.0302). DFS was not statistically different (p = 0.6659) between IDC and ILC. Univariate survival analyses of tumour size, tumour grading and nodal status in our study population were highly statistically significant for OS and DFS (p < 0.0000). CONCLUSION:Patients in our study population with ILC have significantly better OS than patients with IDC. Differences in DFS are not statistically significant.
Authors: Yaliang Yang; Fuhai Li; Liang Gao; Zhiyong Wang; Michael J Thrall; Steven S Shen; Kelvin K Wong; Stephen T C Wong Journal: Biomed Opt Express Date: 2011-07-05 Impact factor: 3.732
Authors: Michèl Schummer; Ann Green; J David Beatty; Beth Y Karlan; Scott Karlan; Jenny Gross; Sean Thornton; Martin McIntosh; Nicole Urban Journal: PLoS One Date: 2010-02-09 Impact factor: 3.240
Authors: Dorien Lobbezoo; Wilfred Truin; Adri Voogd; Rudi Roumen; Gerard Vreugdenhil; Marcus Wouter Dercksen; Franchette van den Berkmortel; Tineke Smilde; Agnes van de Wouw; Roel van Kampen; Johanna van Riel; Natascha Peters; Petronella Peer; Vivianne C G Tjan-Heijnen Journal: Oncotarget Date: 2016-05-17