Literature DB >> 18449496

Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe.

Ju Sin Kim1, Sa Im Lee, Hye Won Park, Jae Heon Yang, Tae-Yong Shin, Youn-Chul Kim, Nam-In Baek, Sung-Hoon Kim, Sang Un Choi, Byoung-Mog Kwon, Kang-Hyun Leem, Mun Yhung Jung, Dae Keun Kim.   

Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).

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Year:  2008        PMID： 18449496     DOI： 10.1007/s12272-001-1172-y

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  18 in total

1.  Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach.

Authors:  Juan J Araya; Huaping Zhang; Thomas E Prisinzano; Lester A Mitscher; Barbara N Timmermann
Journal:  Phytochemistry       Date:  2011-04-15       Impact factor: 4.072

2.  Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols.

Authors:  Shengmin Sang; Jungil Hong; Hou Wu; Jing Liu; Chung S Yang; Min-Hsiung Pan; Vladimir Badmaev; Chi-Tang Ho
Journal:  J Agric Food Chem       Date:  2009-11-25       Impact factor: 5.279

Review 3.  Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Authors:  Armelle T Mbaveng; Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2017-06-02       Impact factor: 5.810

4.  Metabolism of [6]-shogaol in mice and in cancer cells.

Authors:  Huadong Chen; Lishuang Lv; Dominique Soroka; Renaud F Warin; Tiffany A Parks; Yuhui Hu; Yingdong Zhu; Xiaoxin Chen; Shengmin Sang
Journal:  Drug Metab Dispos       Date:  2012-01-13       Impact factor: 3.922

5.  [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.

Authors:  Myoung Ok Kim; Mee-Hyun Lee; Naomi Oi; Sung-Hyun Kim; Ki Beom Bae; Zunnan Huang; Dong Joon Kim; Kanamata Reddy; Sung-Young Lee; Si Jun Park; Jae Young Kim; Hua Xie; Joydeb Kumar Kundu; Zae Young Ryoo; Ann M Bode; Young-Joon Surh; Zigang Dong
Journal:  Carcinogenesis       Date:  2013-11-26       Impact factor: 4.944

6.  [10]-Gingerdiols as the major metabolites of [10]-gingerol in zebrafish embryos and in humans and their hematopoietic effects in zebrafish embryos.

Authors:  Huadong Chen; Dominique N Soroka; Jamil Haider; Karine F Ferri-Lagneau; TinChung Leung; Shengmin Sang
Journal:  J Agric Food Chem       Date:  2013-05-23       Impact factor: 5.279

7.  Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice.

Authors:  Huadong Chen; Dominique N Soroka; Yingdong Zhu; Yuhui Hu; Xiaoxin Chen; Shengmin Sang
Journal:  Chem Res Toxicol       Date:  2013-05-15       Impact factor: 3.739

8.  Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro.

Authors:  Wiratchanee Mahavorasirikul; Vithoon Viyanant; Wanna Chaijaroenkul; Arunporn Itharat; Kesara Na-Bangchang
Journal:  BMC Complement Altern Med       Date:  2010-09-28       Impact factor: 3.659

Review 9.  African flora has the potential to fight multidrug resistance of cancer.

Authors:  Victor Kuete; Thomas Efferth
Journal:  Biomed Res Int       Date:  2015-04-15       Impact factor: 3.411

10.  Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation.

Authors:  Yingdong Zhu; Renaud F Warin; Dominique N Soroka; Huadong Chen; Shengmin Sang
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240
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