Literature DB >> 18449226

Characterization of the Serratia marcescens SdeCDE multidrug efflux pump studied via gene knockout mutagenesis.

Sanela Begic1, Elizabeth A Worobec.   

Abstract

Serratia marcescens is an important nosocomial agent having high antibiotic resistance. A major mechanism for S. marcescens antibiotic resistance is active efflux. To ascertain the substrate specificity of the S. marcescens SdeCDE efflux pump, we constructed pump gene deletion mutants. sdeCDE knockout strains showed no change in antibiotic susceptibility in comparison with the parental strains for any of the substrates, with the exception of novobiocin. In addition, novobiocin was the only antibiotic to be accumulated by sdeCDE-deficient strains. Based on the substrates used in our study, we conclude that SdeCDE is a Resistance-Nodulation-Cell Division family pump with limited substrate specificity.

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Year:  2008        PMID： 18449226     DOI： 10.1139/w08-019

Source DB:  PubMed          Journal:  Can J Microbiol        ISSN： 0008-4166            Impact factor:   2.419


  10 in total

1.  Mutation in the sdeS gene promotes expression of the sdeAB efflux pump genes and multidrug resistance in Serratia marcescens.

Authors:  Hideaki Maseda; Yumiko Hashida; Akihiro Shirai; Takeshi Omasa; Taiji Nakae
Journal:  Antimicrob Agents Chemother       Date:  2011-03-21       Impact factor: 5.191

Review 2.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 3.  Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

Authors:  Lucía Fernández; Robert E W Hancock
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

4.  Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens.

Authors:  Hideaki Maseda; Yumiko Hashida; Rumi Konaka; Akihiro Shirai; Hiroki Kourai
Journal:  Antimicrob Agents Chemother       Date:  2009-09-14       Impact factor: 5.191

5.  A linkage between SmeIJK efflux pump, cell envelope integrity, and σE-mediated envelope stress response in Stenotrophomonas maltophilia.

Authors:  Yi-Wei Huang; Rung-Shiuan Liou; Yi-Tsung Lin; Hsin-Hui Huang; Tsuey-Ching Yang
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

6.  Comprehensive analysis of resistance-nodulation-cell division superfamily (RND) efflux pumps from Serratia marcescens, Db10.

Authors:  Shinsuke Toba; Yusuke Minato; Yuma Kondo; Kanami Hoshikawa; Shu Minagawa; Shiho Komaki; Takanori Kumagai; Yasuyuki Matoba; Daichi Morita; Wakano Ogawa; Naomasa Gotoh; Tomofusa Tsuchiya; Teruo Kuroda
Journal:  Sci Rep       Date:  2019-03-19       Impact factor: 4.379

7.  Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump.

Authors:  Kamil Górecki; Megan M McEvoy
Journal:  PLoS One       Date:  2020-02-12       Impact factor: 3.240

8.  Draft Genome Sequence of Serratia marcescens Strain ZZCCN01, Isolated from the Cardiac Blood of a Beef Cow.

Authors:  Yu-Long Zhang; Fang-Yuan Huang; Cai-Xia Yao; Dong-Jie Cai; Zhi-Sheng Wang; Zhi-Cai Zuo
Journal:  Microbiol Resour Announc       Date:  2020-12-03

9.  Healthcare-associated infections caused by chlorhexidine-tolerant Serratia marcescens carrying a promiscuous IncHI2 multi-drug resistance plasmid in a veterinary hospital.

Authors:  Joanne L Allen; Nicholas P Doidge; Rhys N Bushell; Glenn F Browning; Marc S Marenda
Journal:  PLoS One       Date:  2022-03-17       Impact factor: 3.240

10.  The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.

Authors:  Luisa Sandner-Miranda; Pablo Vinuesa; Alejandro Cravioto; Rosario Morales-Espinosa
Journal:  Front Microbiol       Date:  2018-05-11       Impact factor: 5.640
  10 in total

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