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Literature DB >> 18448829

Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes.

Matthew Blatnik¹, Suzanne R Thorpe, John W Baynes.

Abstract

S-(2-succinyl)cysteine (2SC) is a chemical modification of proteins formed by a Michael addition reaction between the Krebs cycle intermediate, fumarate, and thiol groups in protein--a process known as succination of protein. Succination causes irreversible inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in vitro. GAPDH was immunoprecipitated from muscle of diabetic rats, then analyzed by ultra-performance liquid chromatography-electrospray ionization-mass spectroscopy. Succination of GAPDH was increased in muscle of diabetic rats, and the extent of succination correlated strongly with the decrease in specific activity of the enzyme. We propose that 2SC is a biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins may provide the chemical link between glucotoxicity and the pathogenesis of diabetic complications.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18448829 PMCID： PMC2423376 DOI： 10.1196/annals.1433.047

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

10 in total

1. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.

Authors: T Nishikawa; D Edelstein; X L Du; S Yamagishi; T Matsumura; Y Kaneda; M A Yorek; D Beebe; P J Oates; H P Hammes; I Giardino; M Brownlee
Journal: Nature Date: 2000-04-13 Impact factor: 49.962

2. Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease.

Authors: Jonathan W C Brock; Davinia J S Hinton; William E Cotham; Thomas O Metz; Suzanne R Thorpe; John W Baynes; Jennifer M Ames
Journal: J Proteome Res Date: 2003 Sep-Oct Impact factor: 4.466

3. The pathobiology of diabetic complications: a unifying mechanism.

Authors: Michael Brownlee
Journal: Diabetes Date: 2005-06 Impact factor: 9.461

4. S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

Authors: Nathan L Alderson; Yuping Wang; Matthew Blatnik; Norma Frizzell; Michael D Walla; Timothy J Lyons; Nadja Alt; James A Carson; Ryoji Nagai; Suzanne R Thorpe; John W Baynes
Journal: Arch Biochem Biophys Date: 2006-03-22 Impact factor: 4.013

5. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

Authors: Ying Lin; Anders H Berg; Puneeth Iyengar; Tony K T Lam; Adria Giacca; Terry P Combs; Michael W Rajala; Xueliang Du; Brent Rollman; Weijie Li; Meredith Hawkins; Nir Barzilai; Christopher J Rhodes; I George Fantus; Michael Brownlee; Philipp E Scherer
Journal: J Biol Chem Date: 2004-11-09 Impact factor: 5.157

6. A common mechanism of cellular death induced by bactericidal antibiotics.

Authors: Michael A Kohanski; Daniel J Dwyer; Boris Hayete; Carolyn A Lawrence; James J Collins
Journal: Cell Date: 2007-09-07 Impact factor: 41.582

7. Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.

Authors: Ryoji Nagai; Jonathan W Brock; Matthew Blatnik; John E Baatz; Jennifer Bethard; Michael D Walla; Suzanne R Thorpe; John W Baynes; Norma Frizzell
Journal: J Biol Chem Date: 2007-08-28 Impact factor: 5.157

Review 8. A mechanistic view of mitochondrial death decision pores.

Authors: J E Belizário; J Alves; J M Occhiucci; M Garay-Malpartida; A Sesso
Journal: Braz J Med Biol Res Date: 2007-08 Impact factor: 2.590

9. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress.

Authors: Matthew Blatnik; Norma Frizzell; Suzanne R Thorpe; John W Baynes
Journal: Diabetes Date: 2007-10-12 Impact factor: 9.461

10. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.

Authors: Xueliang Du; Takeshi Matsumura; Diane Edelstein; Luciano Rossetti; Zsuzsanna Zsengellér; Csaba Szabó; Michael Brownlee
Journal: J Clin Invest Date: 2003-10 Impact factor: 14.808

10 in total

32 in total

1. Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.

Authors: Thomas D Niehaus; Jacob Folz; Donald R McCarty; Arthur J L Cooper; David Moraga Amador; Oliver Fiehn; Andrew D Hanson
Journal: J Biol Chem Date: 2018-04-06 Impact factor: 5.157

Review 2. The succinated proteome.

Authors: Eric D Merkley; Thomas O Metz; Richard D Smith; John W Baynes; Norma Frizzell
Journal: Mass Spectrom Rev Date: 2013-09-30 Impact factor: 10.946

3. Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae.

Authors: Faeze Saatchi; Ann L Kirchmaier
Journal: Genetics Date: 2019-05-13 Impact factor: 4.562

Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes.

1. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.

2. Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease.

3. The pathobiology of diabetic complications: a unifying mechanism.

4. S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

5. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

6. A common mechanism of cellular death induced by bactericidal antibiotics.

7. Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.

Review 8. A mechanistic view of mitochondrial death decision pores.

9. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress.

10. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.

1. Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.

Review 2. The succinated proteome.

3. Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae.

Review 4. Features and regulation of non-enzymatic post-translational modifications.

5. Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation.

Review 6. Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research.

Review 7. Fumarate hydratase in cancer: A multifaceted tumour suppressor.

Review 8. Cardiac anaplerosis in health and disease: food for thought.

Review 9. Genie in a bottle: controlled release helps tame natural polypharmacology?

Review 10. Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity.